Journal of
Physiology and Pathophysiology

  • Abbreviation: J. Physiol. Pathophysiol.
  • Language: English
  • ISSN: 2141-260X
  • DOI: 10.5897/JPAP
  • Start Year: 2010
  • Published Articles: 49

Full Length Research Paper

Assessment of endothelial function in subjects with obstructive sleep apnea hypopnea syndrome

Fatoumata Bâ1
  • Fatoumata Bâ1
  • Health Sciences Research and Formation Unit, Gaston Berger University, Saint-Louis, Senegal
  • Google Scholar
Fatou Bintou Sar
  • Fatou Bintou Sar
  • Health Sciences Unit, Laboratory of Physiology and functional explorations, University of Thiès, Thiès, Senegal.
  • Google Scholar
Abdoulaye Bâ
  • Abdoulaye Bâ
  • Laboratory of Physiology and Functional Explorations, University Cheikh Anta Diop, Senegal.
  • Google Scholar


  •  Received: 07 July 2021
  •  Accepted: 10 August 2021
  •  Published: 31 August 2021

Abstract

Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by recurrent episodes of interruption of ventilation responsible for hypoxemia, hypercapnia and hyper activation of the autonomic nervous system. Hypoxemia followed by re-oxygenation promotes the formation of free radicals, oxidative stress and vascular inflammation, leading to endothelial dysfunction. The objective of this cross-sectional study conducted at the laboratory of Physiology of  Gaston Berger University of Saint-Louis was to assess endothelial function during sleep apnea hypopnea syndrome. The endothelial function was explored non-invasively by Endopat 2000. Free and informed consent was required. Data analysis was carried out on Epi Info 7, uni-varied and bi-varied analyzes performed with a significance threshold p <5%. The study involved 42 patients including 69% women and 31% men. The average age was 52.11±8.31 years with a predominance of the (40-50yrs and 50-60yrs). The most frequently medical disorder was hypertension with 71.43%. Over 75% of the subjects were obese or overweight. OSAHS was mild in 35.71% of cases, moderate 38.1% and severe 26.19%. Endothelial dysfunction was found in 27.5% of the subjects. It was most noted in subjects with severe OSAHS, with no statistical significant difference. No significant association was found between endothelial dysfunction, gender, age and body weight. Endothelial function is often impaired during OSAHS. Studies on a larger sample should be done for more conclusive results.

Key words: Endothelial function, sleep apnea hypopnea syndrom, endopat.