Journal of
Physiology and Pathophysiology

  • Abbreviation: J. Physiol. Pathophysiol.
  • Language: English
  • ISSN: 2141-260X
  • DOI: 10.5897/JPAP
  • Start Year: 2010
  • Published Articles: 44

Full Length Research Paper

Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium-challenged rats

Ejike Daniel Eze
  • Ejike Daniel Eze
  • Department of Biomedical Sciences, School of Medicine, Kabale University, Kabale, Uganda.
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Okpa Precious Nwaka
  • Okpa Precious Nwaka
  • Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
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Igbokwe Ugochukwu Vincent
  • Igbokwe Ugochukwu Vincent
  • Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
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Moses Dele Adams
  • Moses Dele Adams
  • Department of Biochemistry, Faculty of Science and Technology, Bingham University, Karu, Nigeria.
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Karimah Mohammed Rabiu
  • Karimah Mohammed Rabiu
  • Department of Biological Sciences, Faculty of Science, Yobe State University, Damaturu, Yobe, Nigeria.
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Ayikobua Emmanuel Tiyo
  • Ayikobua Emmanuel Tiyo
  • Department of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Ishaka - Bushenyi, Uganda.
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  •  Received: 29 November 2018
  •  Accepted: 12 March 2019
  •  Published: 31 May 2019

Abstract

Cadmium produces a wide range of biological dysfunctions in human and laboratory animals where it chiefly affects the testes, whereas, Carpolobia lutea has been known to have antioxidant benefits. This study was intended to investigate the effects of Carpolobia lutea root extracts on testicular hormone function in cadmium-challenged male rats. 48 male Wistar rats (170-190 g) were divided into six groups, each containing eight rats. Experimental animals in control (Group 1) were given 0.2ml/kg body weight (BW) of 10% tween 80; Group two were administered 1mg/kg BW of cadmium (i.p); Group 3 were given 1mg/kg BW of cadmium (i.p) + 100mg/kg BW extract; Group four took 1mg/kg BW of cadmium (i.p) + 200mg/kg BW extract while Group five and six got 100mg/kg and 200mg/kg BW extract respectively. The administration of vehicle and extract was conducted orally for six weeks. Testicular activity of 17 beta-hydrosteroid dehydrogenase (17β-HSD) and serum testosterone, luteinizing and follicle stimulating hormone (LH, FSH) levels were evaluated. Findings indicated that cadmium statistically (p<0.05) lowered testicular 17β-HSD activity and serum testosterone, LH and FSH levels when compared with those of the control group animals. However, Carpolobia lutea and its co-administration notably (p<0.05) elevated the activity of testicular 17β-HSD and levels of serum testosterone, LH and FSH. The study suggests that Carpolobia lutea extract plays a protective function in ameliorating testicular damage caused by cadmium in rats. This is probably due to the extract’s potential in the management of testicular dysfunction and fecundity in animals.

Key words: Carpolobia lutea, polygalaceae, cadmium, 17 beta-hydrosteroid dehydrogenase, testicular function.