Acute toxicity profile of ethanolic extracts of Croton gratissimus Burch and Schrankia leptocarpa DC in rats: Medicinal plants used in the treatment of arterial hypertension in Beninese traditional medicine

Koutchiko Angelus Henok Segla; Attakpa Selidji Eugene; Akotegnon Rodrigue; Guinnin Felix; Senou Maximin; Amoussa Abdou Madjid; Lagnika Latifou; Sina Haziz; Yedomonhan Hounnankpon; Baba-Moussa Farid; Sezan Alphonse; Baba-Moussa Lamine

doi:10.5897/JPAP2021.0143

Journal of
Physiology and Pathophysiology

Abbreviation: J. Physiol. Pathophysiol.
Language: English
ISSN: 2141-260X
DOI: 10.5897/JPAP
Start Year: 2010
Published Articles: 54

Full Length Research Paper

Acute toxicity profile of ethanolic extracts of Croton gratissimus Burch and Schrankia leptocarpa DC in rats: Medicinal plants used in the treatment of arterial hypertension in Beninese traditional medicine

Koutchiko Angelus Henok Segla

Koutchiko Angelus Henok Segla
Laboratory of Physiopathology/Molecular Pharmacology and Toxicology, Department of Animal Physiology, Faculty of Science and Technology, 01 BP: 4521 Cotonou, University of Abomey-calavi, Benin.
Search for this author on:
Google Scholar

Attakpa Selidji Eugene

Attakpa Selidji Eugene
Laboratory of Physiopathology/Molecular Pharmacology and Toxicology, Department of Animal Physiology, Faculty of Science and Technology, 01 BP: 4521 Cotonou, University of Abomey-calavi, Benin.
Search for this author on:
Google Scholar

Akotegnon Rodrigue

Akotegnon Rodrigue
Laboratory of Physiopathology/Molecular Pharmacology and Toxicology, Department of Animal Physiology, Faculty of Science and Technology, 01 BP: 4521 Cotonou, University of Abomey-calavi, Benin.
Search for this author on:
Google Scholar

Guinnin Felix

Guinnin Felix
Laboratory of Physiopathology/Molecular Pharmacology and Toxicology, Department of Animal Physiology, Faculty of Science and Technology, 01 BP: 4521 Cotonou, University of Abomey-calavi, Benin.
Search for this author on:
Google Scholar

Senou Maximin

Senou Maximin
Laboratory of Physiopathology/Molecular Pharmacology and Toxicology, Department of Animal Physiology, Faculty of Science and Technology, 01 BP: 4521 Cotonou, University of Abomey-calavi, Benin.
Search for this author on:
Google Scholar

Amoussa Abdou Madjid

Amoussa Abdou Madjid
Unit of Biochemistry and Molecular Biology, Laboratory of Biochemistry and Bioactives Natural Substances, Faculty of Science and Technology, University of Abomey-calavi 01 BP: 4521 Cotonou, Benin.
Search for this author on:
Google Scholar

Lagnika Latifou

Lagnika Latifou
Unit of Biochemistry and Molecular Biology, Laboratory of Biochemistry and Bioactives Natural Substances, Faculty of Science and Technology, University of Abomey-calavi 01 BP: 4521 Cotonou, Benin.
Search for this author on:
Google Scholar

Sina Haziz

Sina Haziz
Laboratory of Biology and Molecular Typing in Microbiology, Faculty of Science and Technology 05 BP 1604 Cotonou, University of Abomey-calavi, Benin.
Search for this author on:
Google Scholar

Yedomonhan Hounnankpon

Yedomonhan Hounnankpon
Laboratory of Botany and Plant Ecology, Department of Plant Biology, Faculty of Science and Technology 01 BP: 4521 Cotonou, University of Abomey-calavi, Benin.
Search for this author on:
Google Scholar

Baba-Moussa Farid

Baba-Moussa Farid
Laboratory of Microbiology and Food Technology, Department of Plant Biology, Faculty of Science and Technology, University of Abomey-calavi 01 BP: 4521 Cotonou, Benin.
Search for this author on:
Google Scholar

Sezan Alphonse

Sezan Alphonse
Biomembranes and Cellular Signaling Laboratory, Department of Animal Physiology, Faculty of Science and Technology, University of Abomey-calavi 01 BP: 4521 Cotonou, Benin.
Search for this author on:
Google Scholar

Baba-Moussa Lamine

Baba-Moussa Lamine
Laboratory of Biology and Molecular Typing in Microbiology, Faculty of Science and Technology 05 BP 1604 Cotonou, University of Abomey-calavi, Benin.
Search for this author on:
Google Scholar

Article Number - 0C8351E68706
Vol.13(1), pp. 17-26 , January 2022
https://doi.org/10.5897/JPAP2021.0143

Received: 18 October 2021
Accepted: 10 January 2022
Published: 28 February 2022

References

Akinyemi OK, Mendie UE, Smith TS, Oyefolu OA & Coker (2005). Screening of some medicinal plants used in south-west Nigerian traditional medicine for anti-Salmonella typhi activity. Journal of Herbal Pharmacotherapy 5(1):45-60. Crossref

Allouni R (2018). Etude des aspects morphologiques, phytochimiques et pharmacotoxicologiques de la plante Ruta montana. Doctoral dissertation, Université Ferhat Abbas Sétif 1 Faculté des Sciences de la Nature et de la Vie P 120.

Anisuzzaman A, Sugimoto N, Sadik G, Gafur MA (2001). Sub-acute toxicity study of 5-Hydroxy-2 (Hydroxy-Methyl) 4H-pyran-4 One, isolated from Aspergillus fumigatus. Pakistan Journal of Biological Sciences 4:1012-1015. Crossref

Arneson W, Brickell J (2007). Assessment of Liver Function. In: Arneson W, Brickell J, editors. Clinical Chemistry: A laboratory Perspective. 1st ed. Philadelphia: F.A. Davis Company pp. 233-266.

Benjamin MN (1978). Outline of Veterinary Clinical Pathology. (No. 3rd edition). Iowa State University Press pp. 229-232.

Berthet J (2010). Functional role of Toll-Like Receptor 4 expressed by blood platelets as inflammatory immune cells. Doctoral dissertation, University Jean Monnet-Saint-Etienne P 121.

Boudras NK (2020). Contribution à l'étude de l'influence du parasitisme digestif sur certains paramètres sanguins hématologiques, chez des ovins abattus au niveau de l'abattoir municipal de Barika (willaya de Batna). Université Mohamed Khider de Biskra Faculté des sciences exactes et sciences de la nature et de la vie P 6.

Boukandou MM, Mewono L, Aboughe SA (2015). Toxicity studies of medicinal plants used in sub-Saharan Africa. Journal of Ethnopharmacology 174:618-627. Crossref

Boussahel, S (2018). Étude biochimique et histologique de l'effet de quelques extraits des plantes toxiques dans la région de Sétif. Doctoral dissertation P 61.

Bowman WC, Rand MT (1980). Drugs affecting coagulation, fibrinolysis, haematopoiesis and the functioning of blood cells. Textbook of Pharmacology, Oxford: Blackwell Publishers 21:1-53.

Bragança AdS, Tran TN (2017). Increased liver tests. Département de médecine communautaire, de Premier recours et des urgences 3 p. View

Brakch N, Kesseler D (2011). Fiche technique : MCV, MCH, MCHC. Centre suisse de contrôle de qualité 2.

Cloutier L, Rene A, Jutras A (2014). The complete blood count. Pratique clinique. Janvier-février 11(1):28-32.

Danda A (2017). Oxidative stress and diabetic pathology: Activities of ethanolic extract of Phyllanthus amarus Schum. On general metabolism and tissue parameters in streptozotocin-induced diabetes in Wistar rats. University of Abomey-calavi 72 p.

de Santé AH (2011). Surpoids et obésité de l'adulte: prise en charge médicale de premier recours. Recommandation de bonne pratique.Saint-Denis-la-Plaine: Service des bonnes pratiques professionnelles, Haute Autorité de Santé P 2.

Diallo D, Paulsen BS, Liljebäck TH, Michaelsen TE (2003).The malian medicinal plant Trichilia emetica; studies on polysaccharides with complement fixing ability. Journal of Ethnopharmacology 84(2-3):279-287. Crossref

Diezi J (1989). Toxicology: basic principles and clinical implications. Ed Slatkine Geneva pp. 33-44.

Cheyron D, Terzi N, Charbonneau P (2008). New biological markers of acute renal failure. Resuscitation 17(8):775-782. Crossref

Dupont C (2018). Les granulocytes neutrophiles: morphologie, fonctions et méthodes de quantification dans l'espèce bovine. Doctoral dissertation P 8. View

Erslev AJ, Gabuzda TG (1979). Pathologic physiology, mechanisms of diseases. Philadelphia: WB Saunders Company 587-741.

Feres CA, Madalosso RC, Rocha OA, Leite JP, Guimaraes TM, Toledo VP (2006). Acute and chronic toxicological studies of Dimorphandra mollis in experimental animals. Journal of Ethnopharmacology 108(3):450-456. Crossref

Flaujac C, Boukour S, Cramer-Bordé E (2010). Platelets and viruses: an ambivalent relationship. Cellular and Molecular Life Sciences 67(4):545-556. Crossref

Ganong WF (2005). 22 nd ed. Singapore: McGraw Hill. Review of Medical Physiology pp. 515-517.

Greige-Gerges H, Khalil RA, Chahine R, Haddad C, Harb W (2007). Effect of cucurbitacins on bilirubin-albumin binding in human plasma. Life Science 80(6):579-585. Crossref

Gurib-Fakim A (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine 27(1):1-93. Crossref

Hajjaj G (2017). Phytochemical screening, toxicological study andpharmacological valorization of Matricaria chamomilla and Ormenis mixta. (Asteraceae). Doctoral thesis in Drug Sciences. University Mohammed V Rabat P 167.

Hilaly JE, Israili HZ, Lyouss B (2004). Acute and chronic toxicological studies of Ajuva Iva in experimental animals. Journal of Ethnopharmacology 9(1):43-50. Crossref

Huang W, Zhang J, Moore DD (2004). A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. The Journal of Clinical Investigation 113(1):137-143. Crossref

Kasthuri RO, Ramesh B (2018). Toxicity studies on leaf extracts of Alternanthera brasiliana (L.) Kuntze and Alternanthera bettzickiana (Regel) Voss. Journal of Applied Pharmaceutical Science 8(10):82-89. Crossref

Khan AT, Zafar F (2005). Haematological study in response to varying doses of estrogen in broiler chicken. International Journal of Poultry Science 4(10):748-751. Crossref

Kognou ALM, Tchamgoue DA, Tchokouaha YRL, Ngima D, Nthenge-Ngumbau FTVP, Tchinda TA, Gueiffier EC (2018). Acute and sub-chronic toxicity studies of Dichaetanthera africana (Hook. F.) Jacq. Fel.(Melastomataceae) stem bark ethanol extract. Journal of Applied Pharmaceutical Science 8(6):147-155. Crossref

Mabeku LB, Beng VP, Kouam J, Essame O, Etoa FX (2007). Toxicological evaluation of ethyl acetate extract of Cylicodiscus gabunensis stem bark (Mimosaceae). Journal of Ethnopharmacology 111(3):598-606. Crossref

Lawaly IDMM, Idrissa M, Khalid I, Liu Y (2019). Toxicity studies of Acacia nilotica (L.): A review of the published scientific literature. Journal of Herbmed Pharmacology 8(3):163-172. Crossref

Lopez P, Sanchez K, Batlle R, Nerin C (2005). Solid and vapor phase anti-microbial activities of six essential oils susceptibility of selected food borne bacterial and fungal strains. Journal of Agricultural and Food Chemistry 53(17):6939-6946. Crossref

Maner SB, Moosavi L (2019). Mean corpuscular volume (MCV). StatPearls Publishing, Treasure Island (FL) PMID: 31424859.

Mbiri WJ, Musila NM, Ngai ND, Njagi MS, Mbinda MW, Ngugi PM (2017). Acute and sub-chronic oral toxicity study of methanolic extract of Caesalpinia volkensii (harms). South eastern kenya University Digital Respository 8:222. Crossref

Mwale M, Masika PJ & Materechera SA (2014). Effect of medicinal plants on haematology and serum biochemical parameters of village chickens naturally infected with Heterakis gallinarum. Bangladesh Journal of Veterinary Medicine 2(2):99-106. Crossref

Nguyen AKT (2013). Inflammatory role of blood platelets: application in transfusion. Hematology. Université Jean Monnet - Saint-Etienne, French 11.

Obici S, Otobone FJ, da Silva Sela VR, Ishida K, da Silva JC, Nakamura CV, Cortez DA, Audi EA (2008). Preliminary toxicity study of dichloromethane extract of Kielmeyera coriacea stems in mice and rats. Journal of Ethnopharmacology 115(1):131-139. Crossref

OCDE (2001). Acute Oral Toxicity - Acute Class Method. OECD Test Guideline for Chemicals N° 423.

OECD (2001). Acute Oral Toxicity-Acute Toxicity Class Method. In OECD Guidelines for Testing of Chemicals 1:1-14.

Ostrow DJ, Pascolo L, Shapiro SM and C (2003). Tiribelli, New concepts in bilirubin encephalopathy. European Journal of Clinical Investigation 33(11):988-997. Crossref

Prado-Ochoa GM, Abrego-Reyes HV, Velázquez-Sánchez MA, Muñoz-Guzmán AM, Ramírez-Noguera P, Angeles E, Alba-Hurtado F (2014). Subchronic toxicity study in rats of two new ethyl-carbamates with ixodicidal activity. BioMed Research International 2014. Crossref

Rhiouani H, El-Hilaly J, Israili HZ, & Lyoussi B (2008). Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. Journal of ethnopharmacology 118(3):378-386. Crossref

Ringer DH, Dabieh L (1979). Haematology and Clinical Biochemistry. In: The Laboratory Rats. Academic Press, London 1:105-116. Crossref

Schulte AP, Wagner RG, Ostry A, Blanciforti AL, Cutlip RG, Krajnak MK, Miller BD (2007). Work, obesity, and occupational safety and health. American Journal of Public Health 97(3):428-436. Crossref

Sivagurunathan A, Meera KA, Innocent XB (2011). Investigation of immunostimulant potential of Zingiber officinale and Curcuma longa in Cirrhinus mrigala exposed to Pseudomonas aeruginosa - haematological assessment. International Journal of Research in Ayurveda and Pharmacy 2:899-904.

Sodipo AO, Abdulrahman FI, Alemika TE & Gulani IA (2012). Chemical composition and biological properties of the petroleum ether extract of Solanum macrocarpum L. (Local Name: Gorongo). Journal of Pharmaceutical Research International pp. 108-128. Crossref

Tang R, Tian HR, Cai ZJ, Wu HJ, Shen LX & Hu JY (2017). Acute and sub-chronic toxicity of Cajanus cajan leaf extracts. Pharmaceutical Biology 55(1):1740-1746. Crossref