Evaluation of the cytoprotective effects of anti-ulcer agents in acid-alcohol induced gastric ulceration in wistar rats

Nworgu Choice; Celestine Ani; Ugwuishi Emeka; Okorie Pamela; Anyaeji Pamela; Ugwu Princewill; Uzoigwe Jide; Igwe Uzoma; Nwachukwu Daniel

doi:10.5897/JPAP2019.0125

Journal of
Physiology and Pathophysiology

Abbreviation: J. Physiol. Pathophysiol.
Language: English
ISSN: 2141-260X
DOI: 10.5897/JPAP
Start Year: 2010
Published Articles: 54

Full Length Research Paper

Evaluation of the cytoprotective effects of anti-ulcer agents in acid-alcohol induced gastric ulceration in wistar rats

Nworgu Choice

Nworgu Choice
Department of Human Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
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Celestine Ani

Celestine Ani
Department of Human Physiology, College of Medicine, Enugu State University of Science and Technology, Parklane, Enugu Nigeria.
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Ugwuishi Emeka

Ugwuishi Emeka
Department of Human Physiology, College of Medicine, Enugu State University of Science and Technology, Parklane, Enugu Nigeria.
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Okorie Pamela

Okorie Pamela
Department of Human Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
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Anyaeji Pamela

Anyaeji Pamela
Department of Human Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
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Ugwu Princewill

Ugwu Princewill
Department of Human Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
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Uzoigwe Jide

Uzoigwe Jide
Department of Human Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
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Igwe Uzoma

Igwe Uzoma
Department of Human Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi, Nigeria.
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Nwachukwu Daniel

Nwachukwu Daniel
Department of Human Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
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Article Number - CC0E84D61015
Vol.10(1), pp. 10-16 , May 2019
https://doi.org/10.5897/JPAP2019.0125

Received: 18 March 2019
Accepted: 16 April 2019
Published: 31 May 2019

References

Adeniyi B, Jesse A, Lawal A (2012).Prevalence of helicobacter pylori infection among dyspepsia patients in Ibadan, South west Nigeria. African Journal of Microbiology Research 6(14):3399-3402. Crossref

Adeniyi OS, Omale J, Egwuje RJ, Ajayi OS (2016). Effect of selenium treatment on healing of Acetic Acid induced gastric ulcer in albino wistar rats. American Journal of Biomedical Research 4(1):18:22.

Bech PL, Xavier R, Lu N, Nanda NN, Dinaeur M, Podolsky DK (2000). Mechanism of NSAID induced gastrointestinal injury defined using mutant mice. Gastroenterology 119(3):699-705. Crossref

Drini M (2017).Peptic ulcer and non-steroidal anti-inflammatory drugs. Australian Prescriber 40(3):91-93. Crossref

Felix OO, Bamidele OA, Tunde A, David OA (2013). Perforated duodenal ulcer; management in resource poor, semi-urban Nigeria hospital. Nigerian Journal of Surgery 19:13-15.

Hansson LE, Nyren O, Hsung AW, Bergstrom R, Josefsson S, Chow WH, Fraumeni JF Jr, Adami HO (1996). The risk of stomach cancer in patients with gastric or duodenal ulcer disease. New England Journal of Medicine 335(4):242-249. Crossref

Hestvik E, Tylleskev T, Ndeezi G, Grahnquist L, Olafsdottir E, Tumwine JK and Deograttias HK (2011). Prevalence of Helicobacter pylori in HIV-infected, HAART-naïve Ugandan children; a hospital based survey. Journal of the International AIDS Society 14(1):34. Crossref

Modirat AA, Akomolafe OS, Alabi OK, Ogundipe L, Omole JG, Olanisoye KP (2018). Protective effect of methanol extract of Vernonia amygdalina (del) leaf on aspirin induced Gastric ulceration and oxidative mucosal damage in rat's model of Gastric injury. Dose Response 16(3):1559325818785087. Crossref

Parveen K, Michael C. (2012). Clinical Medicine 8th edtn. Pub.Saunders Elsevier Ltd. Edinburgh London, New York pp. 247-251.

Saad BA. Nagala AE, Ayim TA, Umamu AB, Soad SA, Soad KA (2016). Antioxidant, Anti-inflammatory and Anti-ulcer potentials Manuuks Honey against Gastric ulcer in rats. Oxidative Medicine and Cellular Longevity. Crossref

Saheed S, Taofeeq G, Taofik S, Emmanuel A, Abdulhakeem S, Ismaila N, Balogun A (2015). Indomethacin induced gastric ulceration in rats; Protective role of spondias mombira and fiscus exasperate. Toxicology Reports 2:261-267. Crossref

Sidahmed HMA, Abdelwahab SI, Mohan S, Mahmood A, Manal ME, Najiha MH (2013). α-Mangostin from Cratoxylum arborescens (Vahl) Blume demonstrates anti-ulcerogenic property: a mechanistic study. Evidence-Based Complementary and Alternative Medicine. Crossref

Souza D', Dhume VG (1991). Gastric cytoprotection. Indian Journal of Physiology and Pharmacology 35(2):88-98.

Szabo S, Hollander D (1995). Pathways of gastrointestinal protection and repair; mechanism of action of sulcrafate. American. Journal of Medicine 86(6A):23-31. Crossref

Yuan XG, Xie C, Chen J, Xie Y, Zhang kh, Lu NH (2015). Seasonal changes in gastric mucosal factors associated with peptic ulcer bleeding. Experimental and Therapeutic Medicine 9(1):125-130. Crossref