Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 205

Full Length Research Paper

A comparative study of phytochemical profile and antioxidant activity of Sahelian plants used in the treatment of infectious diseases in northern part of Burkina Faso: Acacia seyal Delile and Acacia tortilis (Forssk.) Hayne subsp. raddiana (Savi)

Alphonsine RAMDE-TIENDREBEOGO
  • Alphonsine RAMDE-TIENDREBEOGO
  • Department of Traditional Medicine and Pharmacopoeia-Pharmacy/Research Institute in Health Sciences (MEPHATRA-PH/IRSS), National Center for Scientific and Technological Research (CNRST), 03 BP 7034 Ouagadougou 03, Burkina Faso.
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Moumouni KOALA
  • Moumouni KOALA
  • Department of Traditional Medicine and Pharmacopoeia-Pharmacy/Research Institute in Health Sciences (MEPHATRA-PH/IRSS), National Center for Scientific and Technological Research (CNRST), 03 BP 7034 Ouagadougou 03, Burkina Faso.
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Nabere OUATTARA
  • Nabere OUATTARA
  • Laboratory of Biochemistry and Applied Chemistry (LABIOCA), University of Dedougou S/C Ouaga I Pr Joseph Ki-ZERBO University, 03 BP 7021 Ouagadougou 03, Burkina Faso.
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Marius LOMPO
  • Marius LOMPO
  • Department of Traditional Medicine and Pharmacopoeia-Pharmacy/Research Institute in Health Sciences (MEPHATRA-PH/IRSS), National Center for Scientific and Technological Research (CNRST), 03 BP 7034 Ouagadougou 03, Burkina Faso.
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Innocent Pierre GUISSOU
  • Innocent Pierre GUISSOU
  • Faculty of Health Sciences (FSDS), St Thomas d’Aquin University (USTA), 06 BP 10212 Ouagadougou 06, Burkina Faso.
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  •  Received: 31 July 2019
  •  Accepted: 03 October 2019
  •  Published: 31 October 2019

Abstract

Acacia seyal and Acacia tortilis are used in the treatment of infectious diseases in traditional medicine by population in Northern Burkina Faso. Phytochemical screening by tube test and on HPTLC plates showed the presence of important chemical compounds in these plants. Determination of total phenolic content using method of Folin-Ciocalteu Reagent (FCR) and antioxidant activity by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) test, showed that this biological activity is related to phenolic content. The trunk bark of A. tortilis had an important antioxidant activity with IC50 value of 0.01±0.01 µg/mL due to its highest content (p<0.05) of total phenolic compounds (383.19±0.07 mg GAE/g), of condensed tannins (18.21±0.04%) and flavonoids (66.09±0.06 mg QE/g). This antiradical activity was comparable to that of Trolox used as reference. Radical scavenging activity of leaves of A. seyal was also significant with IC50 value of 0.02±0.01 µg/mL. Its total phenolic compounds, condensed tannins and flavonoids were estimated at 371.43±0.09 mg GAE/g, 14.24±0.00% and 52.72±0.10 mg QE/g, respectively. This study shows that local plants adapted to drought could make an interesting source of molecules with antioxidant property in the prevention and the treatment of infectious diseases.

Key words: Sahel plants, infectious diseases, phenolic compounds, radical scavenging.