Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 224

Full Length Research Paper

Laurus nobilis leaves extract protects against high fat diet-induced type 2 Diabetes in rats

Costantine F. Daher
  • Costantine F. Daher
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Robin I. Taleb
  • Robin I. Taleb
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Mohamad A. Mroueh
  • Mohamad A. Mroueh
  • Department of Pharmaceutical Sciences, School of Pharmacy, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Bilal Nehmeh
  • Bilal Nehmeh
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Hachem Araji
  • Hachem Araji
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Rawan H. Chakas
  • Rawan H. Chakas
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Aimee M. Daccache
  • Aimee M. Daccache
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Kamar H. Eid
  • Kamar H. Eid
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Maria K. El Khoury
  • Maria K. El Khoury
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Pamela F. El Hayek
  • Pamela F. El Hayek
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Hala T. Faddoul
  • Hala T. Faddoul
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Elio Junior Feghali
  • Elio Junior Feghali
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Ahmad G. Ghanem
  • Ahmad G. Ghanem
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Tony P. Haydar
  • Tony P. Haydar
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Abir R. Jammoul
  • Abir R. Jammoul
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Sula H. Nasra
  • Sula H. Nasra
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Nouhad Saade
  • Nouhad Saade
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Donna G. Tahan
  • Donna G. Tahan
  • Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Joey C. Daher
  • Joey C. Daher
  • Gilbert and Rose Marie Chagoury School of Medicine, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Esther Tannoury
  • Esther Tannoury
  • Gilbert and Rose Marie Chagoury School of Medicine, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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Wassim N. Shebaby
  • Wassim N. Shebaby
  • Department of Pharmaceutical Sciences, School of Pharmacy, Lebanese American University, P. O. Box 36, Byblos, Lebanon.
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  •  Received: 27 May 2021
  •  Accepted: 25 August 2021
  •  Published: 30 September 2021

Abstract

Laurus nobilis, commonly known as bay, is used in folk medicine as a remedy for many ailments. The present study investigates the protective effect of L. nobilis leaves extract against high fat diet-induced type 2 diabetes in rats. Animals were divided into group 1 (control), groups 2, 3, and 4 (bay leaves aqueous (AQ) extracts; 50, 100, and 250 mg/kg of body weight, respectively), and groups 5, 6, and 7 (bay leaves methanol/acetone (MeAc) extract; 50, 100, and 250 mg/kg of body weight, respectively). Animals were fed an isocaloric high fat diet for four weeks. The intake of bay leaves extracts was associated with a significant decreases in serum levels of glucose (AQ, 100 and 250 mg/kg; MeAc, 50, 100, and 250 mg/kg) and serum triglyceride (AQ, 250 mg/kg; MeAc, 100, and 250 mg/kg) as well as lower abdominal fat (all AQ and MeAc groups) and body weight gain (MeAc groups only). In conclusion, L. nobilis leaves extract intake provides a protective remedy against high fat diet-induced type 2 diabetes. 

Key words: Laurus nobilis, type 2 diabetes, bay leaves, high fat diet.