Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 223

Full Length Research Paper

Antibacterial and antifungal screening of extracts from six medicinal plants collected in Kinshasa-Democratic Republic of Congo against clinical isolate pathogens

Cimanga Kanyanga R*
  • Cimanga Kanyanga R*
  • Faculty of Pharmaceutical Sciences, University of Kinshasa, P. O. Box 212, Kinshasa XI, Democratic Republic of Congo;Department of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Natural Products and Food Research (NaturA), University of Antwerp, Universiteistplein 1, B-2610, Antwerp, Belgium.
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Kikweta Munduku C
  • Kikweta Munduku C
  • Faculty of Pharmaceutical Sciences, University of Kinshasa, P. O. Box 212, Kinshasa XI, Democratic Republic of Congo
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Tshodi Ehata M
  • Tshodi Ehata M
  • Faculty of Pharmaceutical Sciences, University of Kinshasa, P. O. Box 212, Kinshasa XI, Democratic Republic of Congo
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Nsaka Lumpu
  • Nsaka Lumpu
  • Faculty of Pharmaceutical Sciences, University of Kinshasa, P. O. Box 212, Kinshasa XI, Democratic Republic of Congo
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Mbamu Maya B
  • Mbamu Maya B
  • Faculty of Pharmaceutical Sciences, University of Kinshasa, P. O. Box 212, Kinshasa XI, Democratic Republic of Congo
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Manienga, K
  • Manienga, K
  • Institut Supérieur des Techniques Médicales, P. O. Box 835, Bandundu, République Démocratique du Congo
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Bumoyi, M
  • Bumoyi, M
  • Institut Supérieur des Techniques Médicales, P. O. Box 835, Bandundu, République Démocratique du Congo
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Kambu Kabangu O
  • Kambu Kabangu O
  • Faculty of Pharmaceutical Sciences, University of Kinshasa, P. O. Box 212, Kinshasa XI, Democratic Republic of Congo
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  •  Received: 13 February 2013
  •  Accepted: 27 February 2014
  •  Published: 30 April 2014

Abstract

Results from the in vitro evaluation of the antibacterial and antifungal activities of six plant extracts indicated that the aqueous and the methanol extracts of Acalypha wilkesiana leaves and Ageratum conyzoides leaves exhibited good and efficient antifungal activity against Candida albicans with minimum inhibitory concentration (MIC) of 31.25 µg/ml and minimum fungicidal concentration (MFC) of 62.5 µg/ml) while the methanol extract from Pentaclethra macrophylla inhibited the yeast growth with minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of 62.5 and 125 µg/ml respectively. The aqueous extracts from Acalypha wilkesiana, Ageratum conyzoides, Buccholzia tholoniana seeds, Gulboutia demeusei root and the aqueous and methanol extracts from Pentaclecthra macrophylla stem bark showed good antibacterial activity against Escherichia coli, Klebsiella oxytoca, Proteus mirabilis, Salmonella thyphimurium, Stahylococcus aureus and Shigella flexneri with minimum inhibitory concentration (MIC) of 62.5 µg/ml and minimum bactericidal concentration (MBC) of 125 µg/ml according to the case. These results partly support and justify the traditional use of these plant extracts for treating infections in traditional medicine.

 

Key words: Plant extracts, antibacterial, antifungal, infections.