Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 234

Full Length Research Paper

Hepatoprotective effects of the decoction and macerated leaves of Rhamnus alaternus L. on rats exposed to carbon tetrachloride

Abdelkrim Berroukche*
  • Abdelkrim Berroukche*
  • Laboratory of Biochemistry, Biology Department, Faculty of Sciences, Dr. Tahar Moulay University, Saida 20000, Algeria.
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Khaled Kahloula
  • Khaled Kahloula
  • Laboratory of Biochemistry, Biology Department, Faculty of Sciences, Dr. Tahar Moulay University, Saida 20000, Algeria.
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Miloud Slimani
  • Miloud Slimani
  • Laboratory of Biochemistry, Biology Department, Faculty of Sciences, Dr. Tahar Moulay University, Saida 20000, Algeria.
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Imane Denai
  • Imane Denai
  • Laboratory of Biochemistry, Biology Department, Faculty of Sciences, Dr. Tahar Moulay University, Saida 20000, Algeria.
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Kheira Ammour
  • Kheira Ammour
  • Laboratory of Biochemistry, Biology Department, Faculty of Sciences, Dr. Tahar Moulay University, Saida 20000, Algeria.
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  •  Received: 28 August 2015
  •  Accepted: 02 October 2015
  •  Published: 31 October 2015

Abstract

The plant of Ramnus alaternus L. (Rhamnaceae) has been object of many therapeutic indications for traditional medicine. Many studies have showed a hepatoprotective activity of R. alaternus L. The objective of this study was to compare the hepatoprotective activities of decoction and macerated R. Alaternus L. leaves extracts on rats initially exposed to carbon tetrachloride CCl4 (1 ml/kg). The macerated leaves (250 mg/kg body weight) showed a highly significant hepatoprotective activity (p < 0.01) expressed by a significant decrease in enzymatic biochemical markers such as total bilirubin, alkaline phosphatase (ALP) and transaminases (GOT and GPT). Mean serum biochemical marker levels were 4.5 ± 0.9 mg/dL, 143 ± 3.7, 43.5 ± 9.2 and 32.2 ± 5.1 U/L, respectively. These results illustrate the dominance of the hepatoprotective pharmacological activity of macerated R. alaternus L. leaves.

Key words: Rhamnaceae, traditional medicine, hepatoprotective activity, biochemical markers, alcaline phosphatase.

Abbreviation

(NC): Normal control; (GOT): Glutamic oxaloacetic transaminase; (GPT): Glutamic pyruvic transaminase; (ALP): Alkaline phosphatase; (SD): Standard deviation; (ANOVA): analysis of variance.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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