The potential antibacterial efficacy of guggul gum was checked against six gram-positive and four Gram-negative bacterial strains. The antibacterial activity was assessed by agar well diffusion and two fold serial broth dilution methods. Gram-positive bacterial strains were found to be the most susceptible organisms compare to gram-negative towards guggul gum extract once. The minimum inhibitory concentration (MIC) noticed in concentration range of 0.5 - 2 mg/ml. The bioautography was performed to localize active compound present in crude as well as eluted fraction. Compound 5(1-methyl, 1-amino ethyl)-5- methyl-2-octanone, identified which possessed antibacterial activity by various spectrometric method. The extract of guggul gum possesses significant antibacterial activity againstStaphylococcus aureus.
Key words: Commiphora wightii, guggul gum, antibacterial activity, bioautography, 5(1- methyl, 1-amino ethyl)-5-methyl-2-octanone.
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