Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 223

Full Length Research Paper

In vitro assessments of antibacterial potential of Commiphora wightii (Arn.) Bhandari. gum extract

Kalpesh B. Ishnava, Yogesh N. Mahida and J. S. S. Mohan*
Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar-388 120, Gujarat, India.
Email: [email protected]

  •  Accepted: 11 October 2010
  •  Published: 30 November 2010

Abstract

The potential antibacterial efficacy of guggul gum was checked against six gram-positive and four Gram-negative bacterial strains. The antibacterial activity was assessed by agar well diffusion and two fold serial broth dilution methods. Gram-positive bacterial strains were found to be the most susceptible organisms compare to gram-negative towards guggul gum extract once. The minimum inhibitory concentration (MIC) noticed in concentration range of 0.5 - 2 mg/ml. The bioautography was performed to localize active compound present in crude as well as eluted fraction. Compound 5(1-methyl, 1-amino ethyl)-5- methyl-2-octanone, identified which possessed antibacterial activity by various spectrometric method. The extract of guggul gum possesses significant antibacterial activity againstStaphylococcus aureus.

 

Key words: Commiphora wightii, guggul gum, antibacterial activity, bioautography, 5(1- methyl, 1-amino ethyl)-5-methyl-2-octanone.