Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 222

Review

Medicinal plant-derived compounds as potential phytotherapy forCOVID-19: Future perspectives

Salama M. El-Darier
  • Salama M. El-Darier
  • Botany and Microbiology Department, Faculty of Science, Alexandria University, 21500, Alexandria, Egypt.
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Suzan A. Rashed
  • Suzan A. Rashed
  • Biotechnology Program, Basic and Applied Sciences (BAS) Institute, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab city, Alexandria, Egypt. 2Botany and Microbiology Department, Faculty of Science, Alexandria University, 21500, Alexandria, Egypt.
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Ayat Fayez
  • Ayat Fayez
  • Biotechnology Program, Basic and Applied Sciences (BAS) Institute, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab city, Alexandria, Egypt.
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Sarah S. Hassanein
Muhammed R. Sharaby
  • Muhammed R. Sharaby
  • Botany and Microbiology Department, Faculty of Science, Alexandria University, 21500, Alexandria, Egypt.
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Noran M. Tawfik
  • Noran M. Tawfik
  • Biotechnology Program, Basic and Applied Sciences (BAS) Institute, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab city, Alexandria, Egypt. Department of Zoology, Faculty of Science, Suez Canal University, 41522, Ismailia, Egypt.
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Heba Mansour
  • Heba Mansour
  • Biotechnology Program, Basic and Applied Sciences (BAS) Institute, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab city, Alexandria, Egypt. 5Polymeric Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), 21934, New Borg El-Arab City, Alexandria, Egypt.
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Mohamed Adel
  • Mohamed Adel
  • Biotechnology Program, Basic and Applied Sciences (BAS) Institute, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab city, Alexandria, Egypt. 6Department of Botany and Microbiology, Faculty of Science, Helwan University, Cairo, 11790, Egypt.
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  •  Received: 01 January 2021
  •  Accepted: 11 April 2021
  •  Published: 31 August 2021

Abstract

Currently, the human being faces a contagious virus called SARS-CoV-2 with a high transmission ability, infection, and a relatively high mortality rate, especially for the elderly. All research interest is directed to finding a drug or vaccine to save millions of people’s lives; some have succeeded and applied now in some countries. Medicinal plants represent a green treasure that renders plentiful primary and secondary metabolites characterized by potent biological activities. Interestingly, the secondary metabolites, alkaloids, flavonoids, tannins, and terpenoids, own a broad antiviral history. The plant antiviral capabilities may be due to inhibition of viral attachment to/penetration of the host cell; inhibition of the virus replication; suppressing RNA replication; downregulation of viral proteins translation; interfering with virus non-structural/structural protein; downregulation of virus-induced pro-inflammatory/inflammatory signaling pathways in the host cell, and antioxidant activity thus abating the virus-induced oxidative stress effect. Presently, as we are trapped with a surly virus, there are attempts to exploit the power of nature. Therefore, this review’s main objective is to refer to some medicinal plants or their derivatives that limit the virus’s virulence or alleviate the symptoms associated with this virus.

Key words: SARS-CoV-2, medicinal plants, natural extracts, flavonoids, alkaloids, antiviral.