Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 223

Full Length Research Paper

Antifungal, antibacterial and antioxidant properties of Adansonia digitata and Vitex doniana from Bénin pharmacopeia

Latifou LAGNIKA*, Madjid AMOUSSA, Yann ADJOVI and Ambaliou SANNI
Laboratory of Biochemistry and Molecular Biology, Faculty of Sciences and Technology, Institute of Applied Biomedical Sciences, University of Abomey-Calavi, 04 BP 0320, Cotonou, Republic of Bénin.
Email: [email protected]

  •  Accepted: 15 June 2012
  •  Published: 31 July 2012

Abstract

The dichloromethane, methanol and hydroethanolic extracts from leaves of Vitex donianaand stem bark of Adansonia digitata have been investigated for their antibacterial, antifungal, antioxidant activities and toxicity. The antifungal activity has been investigated against six species of Aspergillus by measuring the mycelial and sporulation inhibitions. The antimicrobial activity was investigated against six Gram positive and Gram negative strains using the microplate dilution method. The phytochemical study was performed on thin layer chromatography and antioxidant activity was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging test. The sporulation inhibition percentage was 70% while mycelial inhibition was less than 40%. The minimum inhibitory concentration ranged from 0.039 to 2.5 mg/ml. In DPPH radical scavenging assay, the effect on reducing free radicals increased in a dose dependent manner. Three extracts out of six were very active compared to quercetol, with inhibition percentage ranging from 77.39 to 86.55%. The results supported the utilization of these plants in infectious diseases and also showed these plants as good sources for antioxidants.

 

Key words: Antifungal, antibacterial, antioxidant, Adansonia digitataVitex doniana.