The present study sought to investigate proximate composition in relation to the short and long term hypoglycemic effects of ethanol/water extracts of Verononiaamygdalina, AzadirachtaindicaandMoringaoleifera on hyperglycemic rats. Hyperglycemia was induced by single intra-peritoneal injection of 0.1 mol/L alloxan monohydrate in citrate buffer (pH = 4.5); dosage = 140 mg/kg; b/w.Hyperglycemic rats received separate dose of 400 mg/kg; bw/12 h of V. amygdalina, A. indicaand M. oleiferafor 14 days.Blood samples were drawn from the rats at regular intervals of 12 h for 48h duration; for short-term study, and subsequently, on days 3, 7, 10 and 14; for long term study, and measured for fasting blood glucose (FBG). Determination of FBG was by glucose oxidase method.V. amygdalina, A. indicaand M. oleifera showed wide variation in crude protein content (CPC), which was within the range of 13.42–37.01%. Total carbohydrate content (TCC) of V. amygdalina and A. indicawas the single highest component with values: TCCV. amygdalina = 40.65% and TCCA. indica= 50.14%; except TCCM. oleifera= 36.65%, which was ≈ CPCM. oleifera = 37.01%. The administration of V. amygdalina, A. indicaand M. oleifera to the rats (0 h ≤ t ≤ 48 h) did not cause significant (p> 0.05) reduction in FBG of hyperglycemic rats compared to the control group. Conversely, the administration of the three leaf extracts caused reduction in FBG in time dependent manner, which was in the order: H[M. oleifera] = 400 mg/kg; bw = 2.73 folds > H[V. amygdalina] = 400 mg/kg; bw = 2.15 folds > H[A. indica] = 400 mg/kg; bw = 1.75 folds; p< 0.05. Comparative proximate composition of V. amygdalina, A. indica and M. oleifera and corresponding capacity of the three leaf extracts to reduce FBG appears to suggest that biomolecules responsible for promoting FBG lowering effects are for the most part the TCC and CPC elements. Keywords: Proximate composition, fasting blood glucose,Verononiaamygdalina, AzadirachtaindicaandMoringaoleifera.

Keywords: Proximate composition, fasting blood glucose,Verononiaamygdalina, AzadirachtaindicaandMoringaoleifera.