Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 225

Full Length Research Paper

Tea tree oil a new natural adjuvant for inhibiting glioblastoma growth

Antonietta Arcella
  • Antonietta Arcella
  • IRCCS Neuromed – Istituto Neurologico Mediterraneo, 18, 86077 Pozzilli IS, Italy.
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Maria Antonietta Oliva
  • Maria Antonietta Oliva
  • IRCCS Neuromed – Istituto Neurologico Mediterraneo, 18, 86077 Pozzilli IS, Italy.
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Sabrina Staffieri
  • Sabrina Staffieri
  • IRCCS Neuromed – Istituto Neurologico Mediterraneo, 18, 86077 Pozzilli IS, Italy.
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Massimo Sanchez
  • Massimo Sanchez
  • Istituto Superiore di Sanita (ISS), Rome Viale Regina Elena, 299, 00161 Roma RM, Italy.
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Michele Madonna
  • Michele Madonna
  • IRCCS Neuromed – Istituto Neurologico Mediterraneo, 18, 86077 Pozzilli IS, Italy.
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Salvatore Castaldo
  • Salvatore Castaldo
  • IRCCS Neuromed – Istituto Neurologico Mediterraneo, 18, 86077 Pozzilli IS, Italy.
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Felice Giangaspero
  • Felice Giangaspero
  • IRCCS Neuromed – Istituto Neurologico Mediterraneo, 18, 86077 Pozzilli IS, Italy.
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Luigi Frati
  • Luigi Frati
  • IRCCS Neuromed – Istituto Neurologico Mediterraneo, 18, 86077 Pozzilli IS, Italy.
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  •  Received: 13 June 2019
  •  Accepted: 07 August 2019
  •  Published: 31 October 2019


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Arcella A, Oliva MA, Staffieri S, Aalberti S, Grillea G, Madonna M, Bartolo M, Pavone L, Giangaspero F, Cantore G, Frati A (2015). In vitro and in vivo effect of human lactoferrin on glioblastoma growth. Journal of Neurosurgery 123(4):1026-1035.


Assmann CE, Cadoná FC, Bonadiman BDSR, Dornelles EB, Trevisan G, Cruz IBMD (2018). Tea tree oil presents in vitro antitumor activity on breast cancer cells without cytotoxic effects on fibroblasts and on peripheral blood mononuclear. Biomedicine and Pharmacotherapy 103:1253-1261.


Bag A, Chattopadhyay RR (2015). Evaluation of synergistic antibacterial and antioxidant efficacy of essential oils of spices in herbs. PLoS ONE 10(7):1-17.


Berghe TV, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P (2014). Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nature Reviews Molecular Cell Biology 15:135-147.


Bing S, Heling P, Ayaz N, Junying Y (2018). Necroptosis in development and diseases. Genes and Development 32(5-6):327-340.


Bozin B, Mimica-Dukic N, Simin N, Anackov GJ (2006). Characterization of the volatile composition of essential oils of some lamiaceae spices and the antimicrobial and antioxidant activities of the entire oils. Journal of Agricultural and Food Chemistry 54(5):1822-1828.


Carson CF, Hammer KA, Riley TV (2006). Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties. Clinical Microbiology Reviews 19(1):50-62.


Calcabrini A, Stringaro A, Toccacieli L, Meschini S., Marra M., Colone M., Salvatore G, Mondellow F, Arancia G, Molinari A (2004). Terpinen-4-ol, The Main Component of Melaleuca Alternifolia (Tea Tree) Oil Inhibits the In Vitro Growth of Human Melanoma Cells. Journal of Investigative Dermatology 122:349 -360.


Cicero C, Bonelli M, Mastrantoni E, Niccolini C, Laurenza M, Larocca LM, Pallini R, Traficante A, Spinsanti P, Ricci-Vitiani L, Arcella A, De Maria R, Nicoletti F, Battaglia G, Melchiorri D (2013). Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas. Cell Death and Differentiation 20(3):396-407.


Corrêa ACNTF, Vericimo MA, Dashevskiy A, Pereira PR, Paschoalin


VMF (2019). Liposomal Taro Lectin Nanocapsules Control Human Glioblastoma and Mammary Adenocarcinoma. Cell Proliferation 24(3):471-477.


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Gautam N, Mantha AK, Mittal S (2014). Essential oils and their constituents as anticancer agents: a mechanistic view. BioMed Research International, Volume 2014, Article ID 154106, 23 pages.


Gottesman MM (2002). Mechanisms of cancer drug resistance. Annual Review of Medicine 53: 615-627.


Hammer KA, Carson CF, Riley TV (2003). Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil. Journal of Applied Microbiology 95:853-860.


Hadfield N (2001). The role of aromatherapy massage in reducing anxiety in patients with malignant brain tumours. International Journal of Palliative Nursing 7(6):279-285.


Hart PH, Brand C, Carson CF, Riley TV, Prager RH, Finlay-Jones JJ (2000). Terpinen4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Inflammation Research 49(11):619-626.


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Justyna S, Susann V, Sabine M, Arne L, Lutz T, Parvin D, Thomas H, Andreas L, Andrea R, Francis K M C, Dieter K, Stefan S, Dieter Adam (2014). TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cellular and Molecular Life Sciences 71(2): 331-348.


Kim SS, Harford JB, Pirollo KF, Chang EH (2015). Effective treatment of glioblastoma requires crossing the blood-brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine. Biochemical and Biophysical Research Communication 468:485-489.


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Lin KW, Liao A, Qutub AA (2015). Simulation predicts IGFBP2-HIF1α interaction drives glioblastoma growth. PLOS Computational Biology 11:e1004169


Mondello F, De Berbardis F, Girolamo A, Cassone A, Salvatore G (2006). In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-suscetible and resistant human pathogenic Candida species. BMC Infectious Diseases 6:158.


Moteki H, Hibasami H, Yamada Y, Katsuzaki H, Imai K, Komiya T (2002). Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not an in human stomach cancer cell line. Oncology Reports 9:757-760.


Nakayama K, Murata S, Ito H, Iwasaki K, Villareal MO, Zheng YW, Matsui H, Isoda H, Ohkohchi N (2017). Terpinen-4ol inhibits colorectal cancer growth via reactive oxygen species. Oncololy Letters 14(2):2015-2024.


Ohgaki H, Kleihues P (2005). Epidemiology and etiology of gliomas. Acta Neuropathology 109 (1): 93-108.


Russo R, Corasaniti MT, Bagetta G, Morrone LA (2015). Exploitation of Cytotoxicity of Some Essential Oils for Translation in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine Volume 2015, Article ID 397821, 9 p.


Sarkaria JN, Kitange GJ, James CD, Plummer R, Calvert H, Weller M, Wick W (2008). Mechanisms of Chemoresistance to alkylating agents in Malignant Glioma. Clinical Cancer Research 14(10):2900-2908.


Schnitzler P, Schon K, Reichling J (2001). Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture. Pharmazie 56:343-347.


Shapira S, Pleban S, Kazanov D, Tirosh P, Arber N (2016). Terpinenol:A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers. PLoS One 11(6):1-13.


Sharifi-Rad J, Antoni Sureda A, Tenore GC, Daglia M, Sharifi-Rad M, Valussi M, Tundis R, Sharifi-Rad M, Loizzo MR, Ademiluyi A, Sharifi-Rad R, Ayatollahi SA, Iriti M (2017). Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems. Molecules 22(1):70.


Shergalis A, Bankhead A, Luesakul U, Muangsin N, Nouri N (2018). Current Challenges and Opportunities in Treating Glioblastoma. Pharmacological Reviews 70(3):412-445.


Stupp R, Weber DC (2005). The role of radio- and chemotherapy in glioblastoma. Onkologie 28(6-7):315-317.


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Taylor RC, Cullen SP, Martin SJ (2008). Apoptosis: controlled demolition at the cellular level. Nature Reviews Molecular Cell Biology 9:231-241.


Tawona NC, Du Plessis L, Gerber M, Hamman J, Du Plessis J (2014). Review of natural compounds for potential skin cancer treatment. Molecules 19(8):11679-11721.


Van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE (2015). Overcoming the blood-brain tumor barrier for effective glioblastoma treatment. Drug Resistance Updates 19:1-12.


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