Journal of
Toxicology and Environmental Health Sciences

  • Abbreviation: J. Toxicol. Environ. Health Sci.
  • Language: English
  • ISSN: 2006-9820
  • DOI: 10.5897/JTEHS
  • Start Year: 2009
  • Published Articles: 194

Extended Abstract

Haemato-pathological effect of dichlorvos on blood picture and liver cells of albino rats

Brown Holy*
  • Brown Holy*
  • Department of Medical Laboratory Science, Rivers State University of Science and Technology, Npkolu, Rivers State, Port Harcourt, Nigeria.
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Kenanagha, B
  • Kenanagha, B
  • Medical Division, Total Upstream Companies Nigeria, Plot 25 Trans Amadi Industrial Layout, Port Harcourt, Rivers State, Nigeria.
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Onwuli, D.O
  • Onwuli, D.O
  • Department of Medical Laboratory Science, Rivers State University of Science and Technology, Npkolu, Rivers State, Port Harcourt, Nigeria.
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  •  Received: 28 December 2014
  •  Accepted: 04 February 2015
  •  Published: 28 February 2015

Abstract

The effect of intraperitonal exposure of dichlorvos an organophosphate (OP) pesticide, on haematology parameters and liver pathology of Wister rats was investigated.  Thirty male albino rats grouped into six (6) of five rats each were injected with 0, 3.7, 7.4, 11.1, 14.8 and 18.5mg/kg of dichlorvos (DDVP) (1 ml/kg) respectively. The haematological parameters measured were red blood cells, haemoglobin; packed cell volume, total white blood cells count and platelet levels. Histological examination of liver tissue was investigated as well. The result of the haematological parameters of the dichlorvos treated rats showed a significant decrease (p<0.05) in the mean values of red blood cells, haemoglobin and packed cell volume and a significant increase (p<0.05) in the total white blood cell count and platelet count which was dose dependent. Changes observed in the liver architecture of the treated rat tissues were feathery looks, fatty changes and centrilobular necrosis. However there was no architectural distortion observed in the liver tissue of the control rats. Dichlorvos had dose dependent target toxicity.

Key words: Liver, toxicity, dichlorvos, pestiscides, haematology.