Journal of
Toxicology and Environmental Health Sciences

  • Abbreviation: J. Toxicol. Environ. Health Sci.
  • Language: English
  • ISSN: 2006-9820
  • DOI: 10.5897/JTEHS
  • Start Year: 2009
  • Published Articles: 208

Full Length Research Paper

Ameliorative effects of melatonin on brain biochemical changes induced by subchronic co-administration of chlorpyrifos and cypermethrin in male Wistar rats

S. B. Idris
  • S. B. Idris
  • Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Nigeria.
  • Google Scholar
S. F. Ambali
  • S. F. Ambali
  • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin, Nigeria.
  • Google Scholar
M. M. Suleiman
  • M. M. Suleiman
  • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
  • Google Scholar


  •  Received: 24 November 2016
  •  Accepted: 21 December 2016
  •  Published: 31 January 2017

References

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Ambali SF, Makinde AO, Shittu M, Adeniyi SA Mowuogwu F (2012). Alleviating effects of Phyllantus niruri on sensorimotor and cognitive changes induced by sub acute chlopyrifos exposure in wistar rats. Am. J. Med. Med. Sci. 2:50-58.
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Bayır A, Kara H, Kıyıcı A, Kıyıcı H, Ak A (2011). The effects of melatonin on oxidative stress markers in an animal model of radiocontrast-induced nephropathy. Biomed. Res. 22(3):311-318.

 
 

Belma G, Aylin G, Filiz H (2001). Cypermethrin-induced oxidative stress in rat brain and liver is prevented by Vitamin E or allopurinol. Toxicol. Lett. 118:139-146.
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Freitas RM, Vasconcelos SM, Souza FC, Vianna GS, Fonteles MM (2005). Oxidative stress in the hippocampus pilocarpine induced status epilepticus in Wistar rats. FEBS J. 272:1307-1312.
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Gulcin I, Beydemir S, Hisar O, Koksal1 E, Reiter RJ (2009). Melatonin administration increases antioxidant enzymes activities and reduces lipid peroxidation in the rainbow trout (Oncorhynchus mykiss, Walbaum) erythrocytes. Turk. J. Vet. Ani. Sci. 33(3):241-245.

 
 

Gulterkin FN, Patat S, Akca H, Altunas I (2006) Melatonin can suppress the cytotoxic effects of chlopyrifos of human HepG2 cell lines. Human Exp. Toxicol. 25(2):47-55.
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Krishnanamoorthy GP, Ventaraman A, Arunkumar RC, Vignesh MM, Arunakaran J (2007). Ameliorative effect of vitamins α-tocopherol and ascorbic acids) on PCB (Aroclor 1254)-induced oxidative stress in rat epidydymal sperm. Reprod. Toxicol. 23:239-245
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Latuszynska J, Luty S, Raszewski G, Tokarska-rodak M, Przebirowska D, Przylepa E, Haratym–maj A (2001). Neurotoxic effect of dermally-applied chlorpyrifos and cypermethrin in Wistar rats. Ann Agric. Environ. Med. 8:163-178

 
 

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Mauriz JL, Molpeceres V, Garcia-Mediavilla MV, Gonzales P, Barrio JP, Gonzales-Galego J (2007). Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in liver of ageing rats. J Pineal Res. 42(3):222-230.
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Raina R, Verma PK, Pankaj NK, Vinay K (2009). Ameliorative effects of α-tocopherol on cypermethrin induced oxidative stress and lipid peroxidation in Wistar rats. Int. J. Med. Med Sci. 1(9):396-399

 
 

Reiter RJ, Tan DX, Rossales-Corales S, Manchester LC (2013). The universal nature, unequal distribution and antioxidant nature of melatonin and its derivatives. Mini Rev. Med. Chem. 13(3): 373-384.

 
 

Satinderpal S, Shamsherjit K, RamjiDB (2013). Chlopyrifos-induced oxidative stress in rats brain and protective effective effect of grape seed extract. J. Phytopharm. 2(3):26-33

 
 

Sekar BM, Jayaraman P, Aarthy P (2010). Screening of acetylcholinesterase in blood and plasma and brain of Wistar rats by NEURELLA D (combination pesticide). Int. J. Pharm. Biol. Sci. 1(2):574-578.

 
 

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Tsakiris S, Angelogianni P, Schulpis KH, Stavridis JC (2000). Protective effect of L-phenylalanine on rat brain acetylcholinesterase inhibition induced by free radicals. Clin. Biochem. 33:103-106
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Uchendu C, Ambali SF, Ayo JO, lasisi IO, Umosen AJ (2013). Subacute chlopyrifos –induced alterations in serum lipids and some oxidative stress biomarkers in male Wistars: beneficial effect of acetyl- L-carnitine. Toxicol. Environ. Chem. 95(3):483-494.
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United States Environmental Protection Agency (USEPA) (2000). Chlorpyrifos: HED Preliminary Risk Assessment for the Reregistration Eligibility Decision (RED) document. Chemical No. 059101. Barcode: D260163, Case: 818975, Submission: S568580

 
 

Wielgomas B, Krechniak J (2007). Effect of α-cypermethrin and chlorpyrifos in a 28‑day study on free radical parameters and cholinesterase activity in Wistar rats. Pol. J. Environ. Stud. 16:91-95.