Serum Paraoxonase (PON1) is a high-density lipoprotein associated esterase capable of hydrolyzing numerous organophosphates and protects low-density lipoprotein against peroxidation. PON1 is believed to play a crucial role in the prevention of cardiovascular disease in animals and PON1 activity has been shown to be low after myocardial infarction, liver disease and during oxidative stress. Here in this article we demonstrated that PON1 level is significantly lowered during the dilated cardiomyopathy (DCM) in dogs. This investigation was carried out on 208 canine serum samples. The serum PON/arylestrase activity was measured in 84 healthy dogs and 124 dogs with dilated cardiomyopathy (DCM) of varying severity. Since heart failure is characterized by oxidative stress, inflammation, deficiency in metabolic substrates and lack of blood supply to heart. Decreased PON activity was significantly observed in advanced stages of DCM.
Key words: DCM, Paraoxonase, Phenyl acetate, High-density lipoprotein, NYHA-classification.
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