Abstract

Our aim in this study is to investigate serum oxidative stress parameters before and after fentanyl analgesia in renal colic which is a severe pain condition and to reveal if there is correlation between fentanyl analgesia and serum oxidative stress parameters in renal colic pain. Thirty two male patients, aged 18 – 65, (mean age 40.7±14.9) who applied to our hospital with the complaint of flank pain and were diagnosed with renal colic were accepted to study. Blood samples were taken from the patients who were diagnosed with renal colic as a result of physical examination and tests (urine analysis, plain radiography, ultrasonography, computed tomography) Pain management of the patients was carried out. Fentanyl (50 - 150 µg), an opioid analgesic, was used in all patients. When patients stated that the pain was definitely gone through, the blood samples were taken again. Blood samples were taken from each participant twice, before and after the analgesic. Malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels were measured from the blood taken. Statistical analysis of the levels which were obtained from before and after the fentanyl treatment was carried out. There were increases in CAT (P < 0.001), SOD (P =0.002), MDA (P < 0.001), and GPx (P = 0.28) activities in response after analgesic administration in the patients. In our study, the treatment of renal colic pain with fentanyl, an opioid analgesic, led to significant increases in the levels of SOD and CAT, which are antioxidant enzymes.

Key words: Renal colic, oxidative stress, analgesic.