Abstract
Coronary atherosclerosis still represents one of the main causes of death. Efficacious prevention should focus on early control of cardiovascular risk factors, including lipid profiles, which unable detect on sub-clinical cases. High-sensitive C-reactive protein (hs-CRP) can prove to be an early cardiac risk predictor. Aims of this study were to compare hs-CRP levels between healthy volunteer with normal blood pressure and those with prehypertension, and to use hs-CRP levels along with other risks to be a cardiac risk predictor. Cross sectional study was done for 6 months duration from January to June 2013 at Kudjab Hospital located in Udonthani province, Thailand. Forty (40) healthy volunteers with pre-hypertension and other 40 volunteers with normal blood pressure were joined in this study. Both groups were similar in the age range and sex. Twelve-hour fasting blood samples were collected from all the participants. Serum was assayed for hs-CRP and lipid profile. All the parameters were statistically significant difference (P<0.001). hs-CRP levels (6.27±7.8 mg/l) was elevated among prehypertension. Odd ratio of hs-CRP for pre-hypertension was 15.45, whereas odd ratio of lipid profiles for prehypertension prediction was only 1.69. However, hs-CRP and lipid profiles were significance related to prehypertension (P<0.001). hs-CRP is early cardiac risk predictor even with normal lipid profile and can help measure additional risk especially subclinical people such as prehypertension.
Key words: Cardiovascular diseases, high-sensitive C-reactive protein (hs-CRP), prehypertension, lipid profile.
