Coronary atherosclerosis still represents one of the main causes of death. Efficacious prevention should focus on early control of cardiovascular risk factors, including lipid profiles, which unable detect on sub-clinical cases. High-sensitive C-reactive protein (hs-CRP) can prove to be an early cardiac risk predictor. Aims of this study were to compare hs-CRP levels between healthy volunteer with normal blood pressure and those with prehypertension, and to use hs-CRP levels along with other risks to be a cardiac risk predictor. Cross sectional study was done for 6 months duration from January to June 2013 at Kudjab Hospital located in Udonthani province, Thailand. Forty (40) healthy volunteers with pre-hypertension and other 40 volunteers with normal blood pressure were joined in this study. Both groups were similar in the age range and sex. Twelve-hour fasting blood samples were collected from all the participants. Serum was assayed for hs-CRP and lipid profile. All the parameters were statistically significant difference (P<0.001). hs-CRP levels (6.27±7.8 mg/l) was elevated among prehypertension. Odd ratio of hs-CRP for pre-hypertension was 15.45, whereas odd ratio of lipid profiles for prehypertension prediction was only 1.69. However, hs-CRP and lipid profiles were significance related to prehypertension (P<0.001). hs-CRP is early cardiac risk predictor even with normal lipid profile and can help measure additional risk especially subclinical people such as prehypertension.
Key words: Cardiovascular diseases, high-sensitive C-reactive protein (hs-CRP), prehypertension, lipid profile.