Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2754

Full Length Research Paper

Transplantation of olfactory ensheathing cells for treatment of inflammatory demyelinating diseases in the central nervous system

  Weijiang Wu1, 2, Qing Lan1*, Hua Lu2, Jie Xu2, Aihua Zhu2, Wenfeng Fang2, Yunzhao Jiang2 and Guozhen Hui3
    1Department of Neurosurgery, the Second Affiliated Hospital of Soochow University, China. 2Department of Neurosurgery, Wuxi Third People’s Hospital, China. 3Department of Neurosurgery, the First Affiliated Hospital of Soochow University, China.  
Email: [email protected]

  •  Accepted: 11 November 2010
  •  Published: 31 December 2010




Demyelinating diseases are typical responses of the white matter of the central nervous system to detrimental factors such as infection, poisoning, degeneration and malnutrition. Of them, inflammatory demyelinating diseases including multiple sclerosis and acute disseminated encephalomyelitis are most commonly found. The current paper discusses the pathomechanism of inflammatory demyelinating diseases and experimental as well as clinical possibilities of olfactory ensheathing cells (OECS) for their treatment, and compares OECS with Schwann cells and oligodendroglias in clinical use. Renewed research efforts are required to investigate the molecular biology of OECS regarding the existing disadvantages of OECS transplant.


Key words: Demyelinating diseases, nerve regeneration, functional recovery