Abstract

Renal failure is a situation in which kidney fails to function adequately. There are two forms of renal failure: acute and chronic. End-Stage renal disease is the final stage of chronic renal failure where there is a progressive, irreversible deterioration in renal function which can be substituted by renal replacement therapy, haemodialysis (HD), peritoneal dialysis, or transplantation. The aim of this study was to investigate changes in various hematological parameters that occur in renal failure patients before and after HD as compared to the control group. The potential effect of dialysis during hematological procedures that occur in renal failure patients was also investigated. The study result showed that most of the hematological parameters measured before and after HD in renal failure patients were either elevated or lowered as compared to the control group. Furthermore, it was observed that most of hematological parameters elevated after HD. More significantly, PT, APTT and fibrinogen were found to increase post-HD while there was a concurrent decrease of platelet counts. The present investigation might help clinicians to initiate precautions before and after dialysis procedures. Therefore, it is recommended that all patients are screened appropriately before and after dialysis to avoid complications.

Key words: Hemodialysis, renal failure, hematological profile.