Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2748

Full Length Research Paper

Evaluation of antiemetic effect of aqueous rhizome extract of Cynodon dactylon against all emetogenic stimuli

Imran Ahmad Khan
  • Imran Ahmad Khan
  • Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Google Scholar
Abdul Aziz
  • Abdul Aziz
  • Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Google Scholar
Muzammal Sattar
  • Muzammal Sattar
  • Departmnent of Physiology and Pharmacology, University of Agriculture, Faisal Abad, Pakistan.
  • Google Scholar
Shaukat Hussain Munawar
  • Shaukat Hussain Munawar
  • Shaukat Hussain Munawar
  • Google Scholar
Zahid Manzoor
  • Zahid Manzoor
  • Shaukat Hussain Munawar
  • Google Scholar
Muhammad Asif Raza
  • Muhammad Asif Raza
  • The Ghazi University, Dera Ghazi Khan, Pakistan.
  • Google Scholar
Ghayoor Fatima
  • Ghayoor Fatima
  • Organic Plant Production and Agroecosystems Research in the Tropics and Subtropics, University of Kassel, Germany.
  • Google Scholar


  •  Received: 30 April 2014
  •  Accepted: 02 July 2014
  •  Published: 30 July 2014

Abstract

This study was an extension of our previous antiemetic work. Many researchers quoted Cynodone dactylon as anti emetic agent but none of them have provided strong pharmacological evidence for it, which drove us for its therapeutic evaluation. Crude aqueous rhizome extract of C. dactylon was evaluated for anti-emetic activity. Emesis was induced by the oral administration of copper sulphate, fresh aqueous extract of Brasica compestris while intravenous Cisplatin was used to induce emesis in fifteen days age chicks of either sex. The anti-emetic activity was determined by calculating the mean decrease in number of emesis in comparison to those of control and standards. C. dactylon (50 and 100 mg/kg body weight orally) showed remarkable emesis suppressant activity when compared with standard drugs chlorpromazine, domperidone and metoclopramide. Both the doses showed remarkable antiemetic activity.

 

Key words: Antiemetic, Cynodone dactylon, chick emesis model, domperidone, metoclopramide, chlorpromazine, Brasica compestris.