Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2740

Full Length Research Paper

Differential antimicrobial activity of the various crude leaves extracts of Sesame radiatum against some common pathogenic micro-organisms

Shittu, L. A. J.1*, Bankole, M. A.2, Ahmed, T.3, Aile, K.4, Akinsanya, M. A.5, Bankole, M. N.6, Shittu, R. K.7 and Ashiru, O. A.1
  1Department of Anatomy, Lagos State University College of Medicine, Ikeja, Nigeria. 2Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Idi-araba, Lagos, Nigeria. 3Department of Microbiology, Drug Quality Control Laboratory/Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria. 4Department of Medical Microbiology, Lagos State University Teaching Hospital, Ikeja, Lagos,  Nigeria. 5Department of Medical Biochemistry, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria. 6Diarrhea Unit, Microbiology Division, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria. 7Medical Microbiology Unit, Bolomedics Laboratories, Egbeda, Nigeria.
Email: [email protected]

  •  Accepted: 12 December 2006
  •  Published: 31 December 2006



Concern about the rising prevalence of antibiotics resistant strains pathogenic micro-organisms has been expressed in the last three decades. However, intensive studies on extracts and biologically active compounds isolated from medicinal plants have also doubled in the last decade. Ethanolic and aqueous extracts of Sesame radiatum leaves were studied for in-vitroantimicrobial activity using agar diffusion method. The gas chromatography-mass spectrometry(GC-MS) phytochemical screening showed the presence of essential oils mainly the phenolic and carboxylic acids groups. The ethanolic extract mildly inhibited the growth of Streptococcus pneumoniae and Candida albicans, while there was no inhibitory effect on Staphylococcus aureusPseudomonas aurogenosa and Escherichia coli. However, aqueous extract exhibited no inhibitory effect on all the five tested micro-organisms.


Key words: Pathogenic micro-organisms, anti-microbial, sesame leaves, GC-MS.