Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2755

Full Length Research Paper

Effects of severe malnutrition on oxidative stress in Wistar rats

  F. F. Akinola1, O. O. Oguntibeju2* and O. O. Alabi1        
  1Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. 2Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa.
Email: [email protected], [email protected]

  •  Accepted: 28 April 2010
  •  Published: 31 May 2010



Oxidative stress was examined in three different types of induced-malnutrition such as marasmus, kwashiorkor and marasmic-kwashiokor. Biomarkers such as superoxide dismutase (SOD), catalase and total protein were determined to assess oxidative stress. The activity of SOD and catalase showed that there was an increased oxidative stress in rats fed with the lowest protein diet (protein-calorie malnutrition group). The study confirmed that of the three states of malnutrition, oxidative stress was more pronounced in marasmic-kwashiokor than in the other two groups.


Key words: Malnutrition, oxidative stress, antioxidants, enzymes, rats.