Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2768

Full Length Research Paper

The pro-inflammatory and anti-inflammatory effects of human peripheral mononuclear cells against the human leukemia cells in middle age with habitual morning swimming

A. C. Huang1, C. M. Jiang2, C. C. Lee3, T. S. Huang4, M. C. Wu1 and Y. Y. Chen3*
1Department of Food Science, National Ping-tung University of Science and Technology, 912, Taiwan (R.O.C.). 2Department of Seafood Science, National Kaohsiung Marine University, 811, Taiwan (R.O.C.) 3Department and Graduate School of Physical Education, Natl. Taiwan Sport University Taichung, 404, Taiwan (R.O.C.). 4Department of Nursing, National Taiwan University Hospital and National Taiwan University College of Medicine, 100, Taiwan (R.O.C.).
Email: [email protected]

  •  Accepted: 24 November 2010
  •  Published: 18 January 2011

Abstract

In order to know if the physiologic stress under cool temperature, as well as the greater immunomodulatory effects of human peripheral mononuclear cells (PBMNC), will cause the pro-inflammatory and anti-inflammatory effects against the proliferation in human leukemia cells U937 in middle age with habitual morning swimming, 14 regular morning swimmers and 11 sedentary lifestyle subjects were enrolled with formal consents in winter season in Taiwan. The isolated PBMNC were stimulated by phytohemagglutinin to obtain the conditioned medium. We consumed no inflammatory status in the morning swimming group from the similar serum CPK, Ig-G, WBC and Ig-A in morning swimming and sedentary lifestyle groups. After being incubated with leukemia cells, the differential effects of the conditioned medium on growth inhibition in U937 were obtained. The cytokines, including IFN-g, TNF-a, IL-10 and IL-4 secreted into the conditioned medium were higher in the morning swimming group than in the sedentary lifestyle group. In conclusion, the greater immunomodulatory effects of PBMNC against the proliferation in U937 in middle age was majorly caused by the effects of the regular moderate swimming exercise rather than the inflammatory effects in cool temperature. The cytokines, which are related to both the anti-inflammatory (such as IL-10 and IL-4) and pro-inflammatory effects, increased at the swimming exercise under cool temperature.

 

Key words: Morning swimming, middle age, leukemia, immunomodulatory, U937, human peripheral mononuclear cells.

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