African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007

AJPP Articles in press

Antihypertensive effects of ethanolic extract of Mucuna flagellipes seed on salt-induced hypertension on Sprague-dawley rats

Article in Press

The need to consider an ethnomedicinal alternative for the management of hypertension has become necessary due to the high cost associated with purchasing conventional antihypertensive drugs and the inability of patients to adhere strictly to the procedures of administration. A total of 40 acclimatized male Wistar rats were used for the study. Five rats were grouped as normotensive control (group A). 25 hypertensive rats...

Author(s):Egharevba E. Jovita, Celestine O. Ani, Igwe.C.Uzoma, Anyaeji S.Pamela, Onwuka C. Kelechi, Adeyomo M. Ayowumi and Nwachukwu C. Daniel

Evaluation of analgesic activity of the ethanolic extract of Pennisetum purpureum in albino mice

Article in Press

Pennisetum purpureum (Elephant or Napier grass) is being used in East Africa and some other parts of the world as animal feed and also in pulp industry. In some parts of South eastern Nigeria where it is popularly known as ‘’Achara‘’ it is a delicacy in some traditional dishes. In recent studies, its nutritional and non-nutritional components reveal that it contains flavoids, saponin, sterols, glycosides, tannins...

Author(s):Igbokwe E. E., Igbokwe G. O. and B. M. Agaie

Prediction of novel therapeutic indication for rosiglitazone based on its reported clinical side effects: Drug repositioning using pharmacovigilance approach

Article in Press

Repositioning of drug using pharmacovigilance approach is the primary objective of this study. Rosiglitazone is the target molecule for this pilot scale study. Rosiglitazone is an anti-diabetic drug of thiazolidinedione class. It works as an insulin sensitizer, by binding to the peroxisome proliferator activated receptor (PPAR) gamma in fat cells and making the cells more responsive to insulin. Rosiglitazone has been...

Author(s):Mrugank Parmar and Shital Panchal

Analgesic properties of snake venom as compared to conventional analgesics

Article in Press

An analgesic is a drug that relieves pain by acting on the central nervous system or peripheral pain receptor mechanisms; while snake venom is a highly modified saliva containing zootoxins which facilitate the immobilization and digestion of prey and defense against threats. Snake venom is toxic but may also have therapeutic effects, e.g. captopril, an Angiotensin-Converting Enzyme inhibitor was developed from the Pit...

Author(s):Caroline Moraa Gesisa and Joseph Gikunju Kangangi

RP-HPLC method development and validation for the simultaneous estimation of atorvastatin, simvastatin and rosuvastatin in bulk and pharmaceutical dosage form

Article in Press

This research was designed to develop and validate a precise, simple, rapid, reliable, more accurate, as well as least time consuming High-Performance Liquid Chromatography (HPLC) technique for simultaneous and individual estimation of atorvastatin, rosuvastatin and simvastatin in whole and in various formulations. This separation was attained chromatographically using blend of methanol and trifluroacetic acid (0.1%) in...

Author(s):Bhuvnesh Kumar Singh, Neelanchal Trivedi, Abhishek Bharadwaj and K. K. Jha

Impact of three modes of cooking on anticholinesterase, antioxidant activities and polyphenols content of eggplant Solanum melongena (Adria variety)

Article in Press

Nowadays, the growing interest in consumption of fruit and vegetables raises the question of cooking impact on their nutritional benefits. Growing evidence suggests that oxidative damage caused by the β-amyloid peptide in the pathogenesis of Alzheimer’s disease may be hydrogen peroxide mediated. Many polyphenols, the most abundant dietary antioxidants, possess stronger neuroprotection against hydrogen peroxide.The...

Author(s):Imen Laib, Malika Barkat and Abdulselam Ertas Mustafa abdullah yilmiz

Scientific and technological prospect of Platonia insignis Mart (Clusiaceae)

Article in Press

The chemodiversity and pharmacological potential of the flora are uncounted and allow the study of native plants, such as Platonia insignis Mart. (Clusiaceae), an exotic plant in Piaui, Brazil. Investigations on the chemical composition of the plant of the family Clusiaceae have shown that they are mainly rich in polysoprenylated benzophenones and xanthones, which have been isolated not only from the resins, but also from...

Author(s):George L. S. Oliveira, Ana Paula dos Santos C. L da Silva, José Carlos C. L. da Silva Filho, Joaquim S. da Costa Júnior, Jorge M. David and Rivelilson Mendes de Freitas

Neurohistological and immunohistochemical effects of prophylactic ethanolic leaf extract of Nauclea Latifolia and Artemether/Lumefantrine on the hippocampus of Plasmodium Berghei-infected mice

Article in Press

The prophylactic effect of ethanolic leaf extract of Nauclea latifolia, widely used in herbal malarial treatment, against the widely used drug Coartem® (Artemether/Lumefantrine) in Plasmodium-infected mice was investigated, and thereafter analysed for organosomatic index, parasitemia, histomorphological and immunohistochemical changes in the hippocampus. Twenty male mice about 6 to 8 weeks weighing 20 to 24 g were...

Author(s):Innocent A. Edagha, Inyang A. Atting and Moses U. Ekanemesang

A review on chemical and pharmacological profile of a novel class of antihyperglycemic drugs: Dipeptidyl protease-4 inhibitors

Article in Press

The dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of anti hyperglycemic agents which were developed for the treatment of type-2 diabetes mellitus by rational drug design, based on an understanding of the mechanism of action and knowledge of the structure of the target enzyme. Glucagon-like peptide-1 (GLP 1) and gastric inhibitory polypeptide (GIP) are hormones secreted by the enteroendocrine cells of the gut in...

Author(s):Himanshu Joshi, Abdul Wadood Siddiqui, Zia Ur Rehman, Afrin Salma and Deepanshu Sharma

FORMULATION AND EVALUTION OF ORAL FAST DISSOLVING FILM OF FEXOFENADINE HYDROCHLORIDE BY QbD APPROACH

Article in Press

The objective of the present investigation was to formulate, evaluate and optimize oral film of Fexofenadine HCl using (Box Behnken) design. In the present investigation an attempt was made to develop mouth dissolving films of Fexofenadine HCl to achieve fast disintegration and dissolution characteristics with improved bioavailability by oral route. Oral films of Fexofenadine HCl were formulated using HPMC E15 premium...

Author(s):Bhusnure O.G

In vivo assessment of the antipyretic activity of tilmicosin

Article in Press

The aim of the present study was to assess the antipyretic activity of the macrolide antibiotic, tilmicosin, at dose levels of 20 and 40 mg/kg of body weight, subcutaneously, in Brewer's yeast-induced fever model in mice. Pyrexia was induced by subcutaneous injection of 20 mL/kg of 20% (w/v) Brewer’s yeast suspension into the animal’s scruff region. Eighteen hours later, feverish animals were treated with either...

Author(s):A. M. El-Mahmoudy, I. M. Gheith, A. A. Elmajdoub and S. K. Awidat

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