African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007

AJBR Articles in press

Article in Press

Acute oral toxicity study of Acacia nilotica bark of aqueous methanolic extract in albino mice

The beneficial use of medicinal plant among rural communities has been reported over century’s medicinal properties and toxicity of the plant varies depending on the part of the plant taken like leaves, roots, stem and bark as well as geographical distribution, climate change and nature of the soil. This study aimed to assess the acute toxicity of Tanzania Acacia nilotica extracts in mice. The information generated is...

Author(s):Raphael Mwezi, Revocutus L Machunda, Hamisi M Malebo

Article in Press

Effects of honey and coconut oil on 4-Hydroxyaminoquinoline N-oxide (4HAQO) induced pancreatic carcinogenesis in rats

Recently, there are many studies focusing on the use of natural products for cancer prevention and treatment. This research work evaluated the effects of honey and coconut oil on 4-Hydroxyaminoquinoline 1-oxide (4HAQO) –induced pancreatic carcinogenesis in rat models. Twenty wistar albino rats were divided into four groups of five rats each. Three groups of rats were injected with 15mg of 4HAQO through the tail vein...

Author(s):Umar AM, Kiru AI, Wudul AM, Alhassan AJ, Ndaguye A, Said SS

Article in Press

In vivo antimalarial activity of bark extracts of Lannea acida (anacardiaceae) and chloroquine against Plasmodium berghei in mice.

Lannea acida plants belong to the family Anacardiaceae. It has been used locally to treat and manage diseases that are contagious. Due to the recent increase in the resistance of malaria parasite to synthetic drugs the search for alternative treatment approach from plant sources is in urgent dimension. The antiplasmodial activity of mice was investigated with L. acida bark extracts. The study of the acute toxicity of the...

Author(s):Olusola A. O, Ogunsina O.I., Ayedogbon S.O, Olusola, A.O

Article in Press

Statistical Optimization of L–glutaminase Production by Trichoderma Species under Solid State Fermentation Using African Locust Beans as Substrate

Six strains of Trichoderma species isolated from soil and air samples were screened for extracellular L–glutaminase production. The highest enzyme producing isolate, T. longibrachiatum was subjected to screening and nutrients optimization experiments under solid state fermentation using a constant weight of African locust beans as substrate. A specific activity of 54.96 U/mg was achieved at 1 % (w/v) glutamine, 0.5 % (w/v)...

Author(s):Musa Olatunji Olarewaju, Humphrey Chukwuemeka Nzelibe, Emmanuel Balogun

Article in Press

Cardioprotective effect of methanolic extract of Magnifera indica (mango) seed flour on acetaminophen-induced cardiotoxicity in albino rats

This study evaluated the effect of methanol extract of mango (Magnifera indica) seed flour on acetaminophen-induced cardiotoxicity in albino rats. Twenty four (24) male and female albino rats were divided into 6 groups consisted of 4 rats: a)Group1: Control group (no induction and treated with distilled water only);b) Group 2 (acetaminophen-induced and untreated); c) Group 3 (acetaminophen-induced and pre-treated with...

Author(s):Nkwocha, Chinelo Chinenye

Article in Press

Improvement and validation of 96 well-microtiter plate-ABTS based assay for estimation of antioxidant activity in green leafy vegetables

The objective of our study was to develop 96 well-microtiter plate 2, 2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) based decolorization assay method for analysis of large number of samples in a single run for the screening of antioxidant activity of various extracts such as food extracts, plasma antioxidants and synthetic antioxidants and optimization was carried out for parameters like concentration,...

Author(s):Meera I, Sivakumar ChV, Tekeba Sisay

Article in Press

Changes in Lipid Class and Fatty Acid Composition during the Development of African pear (Dacryodes edulis) fruit pulp

The pulp of the African pear (D.edulis) fruits were investigated for its oil compositions, major lipid classes and constituents fatty acids from 4 weeks after anthesis (WAA) to fruit maturation. The oil was extracted with n-hexane using soxhlet extractor and characterised by gas chromatography. Fatty acid profile showed a saturated acid content of between 19.5-36.5% and unsaturated fatty acid content of 63.5-80.5%....

Author(s):Uhunmwangho E.S. and Omoregie E.S.

Article in Press

Increased levels of mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2-R) found in serum of patients with breast cancer

The multifunctional transmembrane mannose-6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2-R) has been proposed as a putative prognostic marker in breast cancer. Loss of heterozygosity (LOH) with mutations in the remaining allele have been described at the gene level. We previously reported significant decrease of M6P/IGF2-R at the protein level in cancer cells than normal peritumoral ducts of breast tumors...

Author(s):Lemamy Guy Joseph, Ndeboko Benedicte, Omouessi Serge Thierry and Mouecoucou Justine

Article in Press

BLOOD STABILITY PARAMETERS AS INDICES OF HEMATOLOGICAL DISORDERS REMAIN PRESERVED ON EXPOSURE TO CORCHORUS OLITORUS LEAF CONSUMPTION

This study focused on the integrity retention profile of hematological disorder indices on exposure to ethanol extract of Corchorus olitorus leaf. Seventy two apparently healthy rats were obtained from the animal farm of the Department of Zoology and Environmental Biology University of Nigeria, Nsukka and used for this study. These indices include assessed were Red blood cell distribution width standard deviation, Red...

Author(s):OMEJE KINGSLEY OZIOMA

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