Abstract

Nanoliposomes containing retinol were prepared, and the stability of the incorporated retinol was evaluated. Average particle size of nanoliposomes was 98 nm. Retinol was readily incorporated into nanoliposomes with incorporation efficiencies higher than 99%. The bare retinol in the buffer was almost degraded within 2 days of storage, while at least, over 20% of the initial retinol in nanoliposomes was kept until 8 days in all experimental conditions tested. The incorporated retinol in nanoliposomes was more rapidly degraded as temperature increases under both dark and UV light condition during the whole period of storage, and UV light slightly decreased the stability of retinol in nanoliposomes.

Key words: Retinol, nanoliposome, stability.

Abbreviation

MLVs, Multilamellar vesicles; UV, ultraviolet; PC, L-α-phosphatidylcholine; IE, incorporation efficiency.