African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Characterization and in vitro studies on anticancer activity of exopolymer of Bacillus thuringiensis S13

K. Parthiban
  • K. Parthiban
  • Department of Microbiology, Hajee Karutha Rowther Howdia College (Autonomous) Uthamapalayam - 625533, Tamilnadu, India; Department of Animal science, School of Life Sciences, Bharathidasan University, Tiruchirappalli - 620024,Tamilnadu, India.
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V. Vignesh
  • V. Vignesh
  • Department of Animal science, School of Life Sciences, Bharathidasan University, Tiruchirappalli - 620024,Tamilnadu, India.
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R. Thirumurugan*
  • R. Thirumurugan*
  • Department of Animal science, School of Life Sciences, Bharathidasan University, Tiruchirappalli - 620024,Tamilnadu, India.
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  •  Received: 29 September 2013
  •  Accepted: 29 April 2014
  •  Published: 21 May 2014

Abstract

The objective of the present work was to isolate and characterize the exopolymer producer from a marine environment. The exopolymer producing strain (S13) was identified as Bacillus thuringiensis S13. Characterization of exopolymer shows the presence of brominated compound responsible for cytotoxicity on lung cancer cell line (A549) on XTT assay. An in vitro study of bacterial exopolymer shows the presence of cytotoxic effects on cell lines. Further, active compound in exopolymer responsible for cytotoxicity has to be characterized. The exopolymer produced by B. thuringiensis S13, showed potent cytotoxic effects, and could be used as therapy in cancer after further studies.

 

Key words: Bacillus thuringiensis S13, exopolymer, IR, GCMS analysis and lung cancer cell line.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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