Full Length Research Paper
This study investigates the chemical composition and cytotoxic effects of three essential oils of rosemary, lemon and orange, as well as its effects on breast cancer (MCF-7), human foreskin fibroblasts (HFS) and colorectal carcinoma (HCT116) using gas chromatography-mass spectrometry (GC-MS) methods, leading to identification of a different compound by GC-MS. Eicosapentaenoic acid (13.79%) and heptatriacotanol (13.79%) were the major constituents present in the orange oil. Cytotoxic activity was evaluated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods. Results revealed that essential oils significantly reduced the viability of MCF-7, HFS and HCT116 cells in a concentration-dependent manner. The evaluated essential oils could prove to be promising for future applications in the treatment of cancer-related diseases.
Key words: Anticancer activity, chemical composition, essential oil, cytotoxic effects, cell lines, Mcf-7, Hfs, Hct116, gas chromatography-mass spectrometry (GC–MS), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Copyright © 2023 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0