African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12271

Review

Electrospun fibers for wound healing and treatment of hyperglycemia: A review

Soares J. M. D.
  • Soares J. M. D.
  • Postgraduate Program in Natural Resources of the Semiarid, Federal University of Sao Francisco Valley, Petrolina, PE, Brazil.
  • Google Scholar
Silva J. C.
  • Silva J. C.
  • Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil.
  • Google Scholar
Almeida J. R. G. S.
  • Almeida J. R. G. S.
  • Postgraduate Program in Natural Resources of the Semiarid, Federal University of Sao Francisco Valley, Petrolina, PE, Brazil.
  • Google Scholar
Quintans-Júnior L. J.
  • Quintans-Júnior L. J.
  • Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil.
  • Google Scholar
de Oliveira H. P.
  • de Oliveira H. P.
  • Postgraduate Program in Natural Resources of the Semiarid, Federal University of Sao Francisco Valley, Petrolina, PE, Brazil.
  • Google Scholar


  •  Received: 20 March 2016
  •  Accepted: 03 June 2016
  •  Published: 22 June 2016

References

Agarwal S, Greiner A, Wendorff JH (2009). Electrospinning of Manmade and Biopolymer Nanofibers-Progress in Techniques, Materials, and Applications. Adv. Funct. Mater. 19:2863-2879.
Crossref

 

Akbik D, Ghadiri M, Chrzanowski W, Rohanizadeh R (2014). Curcumin as a wound healing agent. Life Sci. 116(1):1-7.
Crossref

 
 

Almeida JRGS, Guimarães AL, Oliveira AP, Araujo, ECC, Silva FS, Neves LF, Oliveira RA, Sa PGS, Quintans-Junior LJ (2011). Evaluation of hypoglycemic potential and pre-clinical toxicology of Morus nigra L. (Moraceae). Acta Farmaceutica Bonaerense, 30:96-100.

 
 

ADA (American Diabetes Association) (2014). Diagnosis and classification of diabetes mellitus. Diabetes Care 37(1):81-90.

 
 

Araujo ES, Nascimento MLF, de Oliveira HP (2016) Electrospinning of Polymeric Fibres: An Unconventional View on the Influence of Surface Tension on Fibre Diameter. Fib. Text. East. Eur. 24: 22-29.

 
 

Arnolds S, Heise T (2007). Inhaled insulin. Best Pract. Res. Clin. Endocrinol. Metab. 21(4):555-571.
Crossref

 
 

Balducci AG, Cagnani S, Sonvico F, Rossi A, Barata P, Colombo G, Colombo P, Buttini F (2014). Pure insulin highly respirable powders for inhalation. Eur. J. Pharm. Sci. 51:110-117.
Crossref

 
 

Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (2008). Growth factors and cytokines in wound healing. Wound Repair Regen. 16(5):585-601.
Crossref

 
 

Blackstone BN, Palmer AF, Rilo HR, Powell HM (2014). Scaffold architecture controls insulinoma clustering, viability, and insulin production. Tissue Eng. Part A. 20(13-14):1784-1793.
Crossref

 
 

Bertoncelj V, Pelipenko J, Kristl J, Jeras M, Cukjati M, Kocbek P (2014). Development and bioevaluation of nanofibers with blood- derived growth factors for dermal wound healing. Euro. J. Pharm. Biopharm. 88(1):64-74.
Crossref

 
 

Boulton AJ (2008). The diabetic foot: grand overview, epidemiology and pathogenesis. Diabetes Metab. Res. Rev. 24(1):3-6.
Crossref

 
 

Buysschaert M, Medina JL, Bergman M, Shah A, Lonier J (2015). Prediabetes and associated disorders. Endocrine 48:371-393.
Crossref

 
 

Chen H, Jia P, Kang H, Zhang H, Liu Y, Yang P, Yan Y, Zuo G, Guo L, Jiang M, Qi J, Liu Y, Cui W, Santos HA, Deng L (2016). Upregulating Hif-1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound. Adv. Healthc. Mater. 5(8):907-918.
Crossref

 
 

Chen Y, Sloan FA, Yashkin AP (2015). Adherence to diabetes guidelines for screening, physical activity and medication and onset of complications and death. J. Diabetes Complications 29(8):1228-1233.
Crossref

 
 

Choi JS, Leong KW, Yoo HS (2008). In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials. 29(5):587-596.
Crossref

 
 

Chou SF, Carson D, Woodrow KA (2015). Current strategies for sustaining drug release from electrospun nanofibers. J. Control. Release 220:584-591.
Crossref

 
 

Cui W, Li X, Zhou S, Weng J (2007). Investigation on Process Parameters of Electrospinning System through Orthogonal Experimental Design. J. Appl. Polym. Sci. 103(1):3105-3112.
Crossref

 
 

da Costa FPC, Araujo ES, NASCIMENTO MLF, de Oliveira HP (2015) Electrospun Fibers of Enteric Polymer for Controlled Drug Delivery. Int. J. Polym. Sci. Article ID 902365:1-8.

 
 

Ding F, Deng H, Du Y, Shi X, Wang Q (2014). Emerging chitin and chitosan nanofibrous materials for biomedical applications. Nanoscale 6(16):9477-9493.
Crossref

 
 

DiSanto RM, Subramanian V, Gu Z (2015). Recent advances in nanotechnology for diabetes treatment. Wiley Interdiscip. Rev. Nanomed Nanobiotechnol. 7(4):548-564.
Crossref

 
 

Du Y, Zhang W, Wang ML (2016). Sensing of salivary glucose using nano-structured biosensors. Biosensors 6(1): 1-14. Formhals A. US patent 1,975,504, 1934.

 
 

Gainza G, Villullas S, Pedraz JL, Hernandez RM, Igartua M (2015). Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration. Nanomedicine. 11(6):1551-1573.
Crossref

 
 

He Q, Zhang X, Han B, Xu J, Tang K, Fu Z, Yin H (2014). A synergistic therapeutic scheme for hyperglycemia and nephrotic disorders in diabetes. Theranostics. 4(5):556-564.
Crossref

 
 

Hu X, Liu S, Zhou G, Huang Y, Xie Z, Jing X (2014). Electrospinning of polymeric nanofibers for drug delivery applications. J. Control. Release 185:12-21.
Crossref

 
 

Inouye KA, Bisch FC, Elsalanty ME, Zakhary I, Khashaba RM, Borke JL (2014). Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes. Implant Dent. 23(3):319-327.
Crossref

 
 

International Diabetes Federation IDF (2015). IDF Atlas, 7thed. Brussels, Belgium: International Diabetes Federation.

 
 

Ita K (2015). Transdermal delivery of drugs with microneedles: Strategies and Outcomes. J. Drug Deliv. Sci. Technol. 29:16-23.
Crossref

 
 

Jang S, Kim Y, Oh JH (2015). Influence of Processing Conditions and Material Properties on Electrohydrodynamic Direct Patterning of a Polymer Solution. ‎J. Electron. Mater. 45(4):1-8.

 
 

Kant V, Gopal A, Kumar D, Pathak NN, Ram M, Jangir BL, Tandan SK, Kumar D (2015). Curcumin-induced angiogenesis hastens wound healing in diabetic rats. J. Surg. Res. 193(2): 978-988.
Crossref

 
 

Kant V, Gopal A, Pathak NN, Kumar P, Tandan SK, Kumar D (2014). Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats. Int. Immunopharmacol. 20(2):322-330.
Crossref

 
 

Krausz AE, Adler BL, Cabral V, Navati M, Doerner J, Charafeddine RA, Chandra D, Liang H, Gunther L, Clendaniel A, Friedman JM, Nosanchuk JD, Friedman AJ (2015). Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agente. Nanomedicine. 11(1):195-206.

 
 

Kuricová K, Pácal L, Šoupal S, Prázný M, Kaňková K (2016). Effect of glucose variability on pathways associated with glucotoxicity in diabetes: Evaluation of a novel in vitro experimental approach. Diabetes Res. Clin. Pract. 114:1-8.
Crossref

 
 

Lee CH, Chang SH, Chen WJ, Hung KC, Lin YH, Liu SJ, Hsieh MJ, Pang JH, Juang JH (2015). Augmentation of diabetic wound healing and enhancement of collagen content using nanofibrous glucophage-loaded collagen/PLGA scaffold membranes. J. Colloid. Interface Sci. 439:88-97.
Crossref

 
 

Lee CH, Hsieh MJ, Chang SH, Lin YH, Liu SJ, Lin TY, Hung KC, Pang JH, Juang JH (2014). Enhancement of diabetic wound repair using biodegradable nanofibrous metformin-eluting membranes: in vitro and in vivo. ACS Appl. Mater. Interfaces 6(6):3979-3986.
Crossref

 
 

Lenzen S (2008). The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 51(2):216-226.
Crossref

 
 

Li WJ, Danielson KG, Alexander PG, Tuan RS (2003). Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(epsilon-caprolactone) scaffolds. J. Biomed. Mater. Res. A. 67(4):1105-1114.
Crossref

 
 

Li X, Deng X, Yuan M, Xiong C, Huang Z, Zhang Y, Jia W (2000). In Vitro Degradation and Release Profiles of Poly-DLLactide-Poly(ethylene glycol) Microspheres with Entrapped Proteins. J. Appl. Polym. Sci. 78:140-148.
Crossref

 
 

Ling MH, Chen MC (2013). Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats. Acta Biomater. 9(11):8952-8961.
Crossref

 
 

Ma J, Liu J, Yu H, Chen Y, Wang Q, Xiang L (2015). Beneficial Effect of Metformin on Nerve Regeneration and Functional Recovery After Sciatic Nerve Crush Injury in Diabetic Rats. Neurochem. Res. 41(5):1130-1137.
Crossref

 
 

Merrell JG, McLaughlin SW, Tie L, Laurencin CT, Chen AF, Nair LS (2009). Curcumin Loaded Poly(ε-Caprolactone) Nanofibers: Diabetic Wound Dressing with Antioxidant and Anti-inflammatory Properties. Clin. Exp. Pharmacol. Physiol. 36(12):1149-1156.
Crossref

 
 

Mitchell AC, Briquez PS, Hubbell JA, Cochran JR (2016). Engineering growth factors for regenerative medicine applications.

 
 

Moura LI, Dias AM, Suesca E, Casadiegos S, Leal EC, Fontanilla MR, Carvalho L, de Sousa HC, Carvalho E (2014). Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice. Biochim. Biophys. Acta. 1842(1):32-43.
Crossref

 
 

Nacht B, Larndorfer C, Sax S, Borisov SM, Hajnsek M, Sinner F, List-Kratochvil EJW, Klimant I (2015). Integrated catheter system for continuous glucose measurement and simultaneous insulin infusion. Biosen. Bioelectron. 64:102-110.
Crossref

 
 

Nishimura A, Hayakawa T, Yamamoto Y, Hamori M, Tabata K, Seto K, Shibata N (2012). Controlled release of insulin from self-assembling nanofiber hydrogel, PuraMatrix™: Application for the subcutaneous injection in rats. Eur. J. Pharm. Sci. 45(1-2):1-7.
Crossref

 
 

Radenković M, Stojanović M, Prostran M (2016). Experimental diabetes induced by alloxan and streptozotocin: The current state of the art. J. Pharmacol. Toxicol. Methods 78:13-31.
Crossref

 
 

Ramasamy R, Ramachandran K, Philip GG, Ramachandran R, Therese HA, Kumar GG (2015). Design and development of Co3O4/NiO composite nanofibers for the application of highly sensitive and selective non-enzymatic glucose sensors. RSC ADVANCES 5(93): 76538-76547
Crossref

 
 

Salazar JJ, Ennis WJ, Koh TJ (2015). Diabetes Medications: Impact on Inflammation and Wound Healing. J. Diabetes Complications (15): 1056-8727.

 
 

Schneider A, Wang XY, Kaplan DL, Garlick JA, Egles C (2009). Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomater. 5(7):2570-2578.
Crossref

 
 

Sharma A, Gupta A, Rath G, Goyal A, Mathura RB, Dhakate SR (2013). Electrospun composite nanofiber-based transmucosal patch for anti-diabetic drug delivery. J. Mater. Chem. B 1:3410-3418.
Crossref

 
 

Siersma V, Thorsen H, Holstein PE, Kars M, Apelqvist J, Jude EB, Piaggesi A, Bakker K, Edmonds M, Jirkovská A, Mauricio D, Ragnarson Tennvall G, Reike H, Spraul M, Uccioli L, Urbancic V, van Acker K, van Baal J, Schaper NC (2014). Health-Related Quality of Life Predicts Major Amputation and Death, but Not Healing, in People With Diabetes Presenting With Foot Ulcers: The EurodialeStudy. Diabetes Care 37(3):694-700.
Crossref

 
 

Singh N, Armstrong DG, Lipsky BA (2005). Preventing Foot Ulcers in Patients With Diabetes. J. Am. Med. Assoc. 293(2):217-28.
Crossref

 
 

Senthamizhan A, Balusamy B, Uyar T (2016). Glucose sensors based on electrospun nanofibers: a review. Anal. Bioanal. Chem. 408:1285-1306.
Crossref

 
 

Stumvoll M, Goldstein BJ, van Haeften TW (2005). Type 2 diabetes: principles of pathogenesis and therapy. Lancet. 365(9467):1333-1346.
Crossref

 
 

Sun X, Cheng L, Zhao J, Jin R, Sun B, Shi Y, Zhang Lu, Zhang Y, Cui W (2014). bFGF-grafted electrospun fibrous scaffolds via poly(dopamine) for skin wound healing. J. Mater. Chem. B. 2:3636-3645.
Crossref

 
 

UK Prospective Diabetes Study UKPDS. (1998). Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 352(9131):854-865.
Crossref

 
 

Wang Z, Qian Y, Li L, Pan L, Njunge LW, Dong L, Yang L (2016). Evaluation of emulsion electrospun polycaprolactone/hyaluronan/ epidermal growth factor nanofibrous scaffolds for wound healing. J. Biomater. Appl. 30(6):686-698.
Crossref

 
 

Xie Z, Paras CB, Weng H, Punnakitikashem P, Su LC, Vu K, Tang L, Yang J, Nguyen KT (2013). Dual growth factor releasing multi-functional nanofibers for wound Healing. Acta biomater. 9(12):9351-9359.
Crossref

 
 

Yang G, Wang J, Li L, Ding S, Zhou S (2014). Electrospun Micelles/Drug-Loaded Nanofibers for Time-Programmed Multi-Agent Release. Macromol. Biosci. 14(7):965-976.
Crossref

 
 

Yang Y, Xia T, Chen F, Wei W, Liu C, He S, Li X (2012). Electrospun Fibers with Plasmid bFGF Polyplex Loadings Promote Skin Wound Healing in Diabetic Rats. Mol. Pharm. 9(1):48-58.
Crossref

 
 

Yang Y, Xia T, Zhi W, Wei L, Weng J, Zhang C, Li X (2011). Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor. Biomaterials. 32(18):4243-4254.
Crossref

 
 

Yang J, Tang S, Cheke RA (2016). The regulatory system for diabetes mellitus: Modeling rates of glucose infusions and insulin injections Commun Nonlinear Sci Numer Simul. 37:305-325.
Crossref

 
 

Yao L, Haas TW, Guiseppi-Elie A, Bowlin GL, Simpson DG, Wnek GE (2003). Electrospinning and Stabilization of Fully Hydrolyzed Poly(Vinyl Alcohol) Fibers. Chem. Mater. 15(9):860-1864.
Crossref

 
 

Yong C, Wang Z, Zhang X, Shi X, Ni Z, Fu H, Ding G, Fu Z, Yin H (2014). The therapeutic effect of monocyte chemoattractant protein-1 delivered by an electrospun scaffold for hyperglycemia and nephrotic disorders. Int J Nanomedicine. 17(9):985-993.

 
 

Yu H, Jia Y, Yao C, Lu Y (2014). PCL/PEG core/sheath fibers with controlled drug release rate fabricated on the basis of a novel combined technique. Int. J. Pharm. 469(1):17-22.
Crossref

 
 

Zhang Y, Wei W, Lv P, Wang L, Ma G (2011). Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin. Eur. J. Pharm. Biopharm. 77(1):11-19.
Crossref

 
 

Zhou S, Deng X, Yang H (2003). Biodegradable poly(ɛ-caprolactone)-poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system. Biomaterials 24(20):3563-3570.
Crossref

 
 

Zong X, Ran S, Kim KS, Fang D, Hsiao BS, Chu B (2003). Structure and Morphology Changes during in Vitro Degradation of Electrospun Poly(glycolide-co-lactide) Nanofiber Membrane. Biomacromolecules 4(2):416-423.
Crossref