African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 418

Full Length Research Paper

Association of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients in Dakar

Nènè Oumou Kesso Barry
  • Nènè Oumou Kesso Barry
  • Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta DIOP, Dakar, Senegal.
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Moustapha Djite
  • Moustapha Djite
  • Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta DIOP, Dakar, Senegal.
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Pape Matar Kandji
  • Pape Matar Kandji
  • Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal.
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El Hadji Malick Ndour
  • El Hadji Malick Ndour
  • Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta DIOP, Dakar, Senegal.
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Michel Assane Ndour
  • Michel Assane Ndour
  • Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal.
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Demba Diedhiou
  • Demba Diedhiou
  • Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal.
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Gueye-Tall Fatou
  • Gueye-Tall Fatou
  • Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta DIOP, Dakar, Senegal.
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Alix Palanga Koboyo
  • Alix Palanga Koboyo
  • Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal.
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Ndeye Marieme Thioune
  • Ndeye Marieme Thioune
  • Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal.
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Najah Fatou Coly
  • Najah Fatou Coly
  • Diamniadio Children Hospital, Dakar, Senegal.
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Dominique Doupa
  • Dominique Doupa
  • Department of Medical Biochemistry, Saint-Louis University, Saint-Louis, Senegal.
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Maimouna Ndour Mbaye
  • Maimouna Ndour Mbaye
  • Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal.
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Aynina Cisse
  • Aynina Cisse
  • Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta DIOP, Dakar, Senegal.
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Pape Amadou Diop
  • Pape Amadou Diop
  • Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta DIOP, Dakar, Senegal.
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Philomène Lopez Sall
  • Philomène Lopez Sall
  • Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta DIOP, Dakar, Senegal.
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Papa Madieye Gueye
  • Papa Madieye Gueye
  • Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta DIOP, Dakar, Senegal.
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  •  Received: 22 December 2020
  •  Accepted: 07 October 2021
  •  Published: 31 October 2021

Abstract

The association between hyperuricemia and metabolic syndrome (MS) has been reported in many studies. The authors performed this cross-sectional study to determine the association between hyperuricemia and the MS among diabetic patients in Dakar. Type 2 diabetic patients received as part of their follow-up at the Marc Sankalé Center of Abass Ndao Hospital in Dakar were enrolled. For each patient, blood samples and 24 h urine collection were performed. Hyperuricemia was defined for uric acid concentrations > 416 µmol/l in men and > 357 µmol/l in women and the MS was evaluated according to WHO criteria. Statistical analysis was done using the XLSTAT 2019 software. A total of 153 type 2 diabetic patients were included with an average age of 56.63 years. Thirty-one percent (31%) of patients had metabolic syndrome and 32% of them had hyperuricemia. Significant correlations were found between serum uric acid and some components of the MS including triglyceride levels (r = 0.25, p = 0.002), microalbuminuria (r = 0.19, p = 0.018), and fasting glucose (r = - 0.22, p = 0.005). The authors found that hyperuricemia is frequent in patients with MS and this could be considered as a biomarker associated with the presence of this syndrome.

 

Key words: Hyperuricemia, metabolic syndrome, type 2 diabetes, uric acid.