African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

The anti-inflammatory activities of twelve Nigerian medicinal plants: Inhibition of NfkB, activation of Nrf2, and antioxidant content

Dorothy VanderJagt
  • Dorothy VanderJagt
  • Department of Biochemistry and Molecular Biology, University of New Mexico, USA.
  • Google Scholar
Lucy Hunsaker
  • Lucy Hunsaker
  • Department of Biochemistry and Molecular Biology, University of New Mexico, USA.
  • Google Scholar
Sunday O. Otimenyin
  • Sunday O. Otimenyin
  • Department of Pharmacologgy, Faculty of Pharmaceutical Science, University of Jos, Nigeria.
  • Google Scholar
Mary O. Uguru
  • Mary O. Uguru
  • Department of Pharmacologgy, Faculty of Pharmaceutical Science, University of Jos, Nigeria.
  • Google Scholar


  •  Received: 10 September 2021
  •  Accepted: 07 January 2022
  •  Published: 31 January 2022

References

Abbas AK, Lichtman AH, Pillai S (2012). Cellular and Molecular Immunology 7th edition. Elsevier Saunders, Philadelphia.

 

Anrather J, Racchumi G, Iadecola C (2006). NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. Journal of Biological Chemistry 281(9):5657-5667.
Crossref

 

Baker RG, Hayden MS, Ghosh S (2011). NF-kB, inflammation, and metabolic disease. Cell Metabolism 13(1):11-22.
Crossref

 

Benzie IF, Strain JJ (1999). Ferric reducing/antioxidant power assay: direct measurement of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods in Enzymology 299:15-27.
Crossref

 

Borokini T (2011). Conservation and Utilization of Medicinal Plants in Nigeria. Lambert Academic Publishing GMBH & Co.KG; Berlin, 2011.

 

Braca A, Politi M, Sanogo R, Sanou H, Morelli I, Pizza C, de Tommasi N (2003). Chemical composition and antioxidant activity of phenolic compounds from wild and cultivated Sclerocarya birrea (Anacardiaceae) leaves. Journal of Agriculture and Food Chemistry 51(23):6689-6695.
Crossref

 

Chen XL, Kunsch C (2004). Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Current Pharmaceutical Design 10(8):879-891.
Crossref

 

Christodoulidis G, Vittoria TJ, Fudim M, Lerakis S, Kosmas CE (2014). Inflammation in coronary artery disease. Cardiology in Review 22(6):279288.
Crossref

 

Dalziel JM (1937). The useful plants of West Tropical Africa. The Crown Agents for the Colonies, London pp. 552-560.

 

Deck LM, Whalen LJ, Hunsaker LA, Royer RE, Vander Jagt D (2017). Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes. Bioorganic and Medicinal Chemistry 25(4):1423-1430.
Crossref

 

Deng WG, Zhu Y, Wu KK (2003). Up-regulation of p300 binding and p50 acetylation in in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation. Journal of Biological Chemistry 278(7):4770-4777.
Crossref

 

Farber J (1994). Mechanism of cell injury by activated oxygen. Environmental Health Perspectives 102(suppl 10):17-24.
Crossref

 

Fasinu PS, Bouic PJ, Rosenkranz B (2012). An overview of the evidence and mechanisms of herb-drug interactions. Frontiers in Pharmacology 3:69.
Crossref

 

Fernandes JV, Cobucci RN, Jatoba CA, Fernandes TA, de Azevedo JW, de Araujo JM (2015). The role of the mediators of inflammation in cancer development. Pathology &Oncology Research 21(3):527-534.
Crossref

 

Fotio AL, Dimo T, Nguelefack TB, Dzeufiet PD, Ngo Lemba E, Temdie RJ, Ngueguim F, Olleros ML, Vesin D, Dongo E, Kamtchouing P, Garcia I (2009). Acute and chronic anti-inflammatory properties of the stem bark aqueous and methanol extracts of Sclerocarya birrea. Inflammopharmacology 17(4):229-237.
Crossref

 

Ghosh N, Ali A, Ghosh R, Das S, Mandal SC, Pal M (2016). Chronic inflammatory diseases: progress and prospect with herbal medicine. Current Pharmaceutical Design 22(2):247-264.
Crossref

 

Gilbert B, Alves LF (2003).Synergy in plant medicines. Current medicinal chemistry 10(1):13-20.
Crossref

 

Gupta SC, Sundaram C, Reuter S, Aggarwal BB (2010). Inhibiting NF-kappaB activation by small molecules as a therapeutic strategy. Biochimica Biophysica Acta 1799(10-12):775-787.
Crossref

 

Gurib-Fakim A (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine 27(1):1-93.
Crossref

 

Huang D, Ou B, Prior RL (2005). The chemistry behind antioxidant capacity assays. Journal of Agricultural Food Chemistry 53(6):1841-1856.
Crossref

 

Ilodigwe E, Okonkwo BE, Agbata CA, Ajaghaku DL, Eze PM. (2014). Wound healing activity of ethanol leaf extract of Erythrina senegalensis. British Journal of Pharmaceutical Research 4:531-540.
Crossref

 

James PB, Wardle J, Steel A, Adams J (2018). Traditional, complementary and alternative medicine use in Sub-Saharan Africa: a systematic review. British Medical Journal Global Health 3(5):e000895.
Crossref

 

Kafuti YS, Alemika TE, Ojerinde OS, Balogun O, Alamika TE, Taba KM, Mpiana PT, Kindombe NM (2019). Antioxidant and antiproliferative activities of the stem bark extract and fractions of Boswellia dalzielii Hutch. International Journal of Pharmacognosy and Phytochemical Research 11(3):177-182.

 

Kawabata K, Yoshioka Y, Terao J (2019). Role of intestinal microbiota in the bioavailability and physiological functions of dietary polyphenols. Molecules 24(2):370-395.
Crossref

 

Keum YS (2011). Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications. Annals of the New York Academies of Science 1229(1):184-189.
Crossref

 

Kone WM, Solange KN, Dosso M (2011). Assessing Sub-Saharan Erythrina for efficacy: Traditional uses, biological activities and phytochemistry. Pakistan Journal of Biological Science 14(10):560-571.
Crossref

 

Kosmas CE, Silverio D, Sourlas A, Montan PD, Guzman E, Garcia M (2019). Anti-inflammatory therapy for cardiovascular disease. Annals of Translational Medicine 7(7):147-153.
Crossref

 

Kundu JK, Surh YJ (2008). Inflammation: gearing the journey to cancer. Mutation Research Review 659(1-2):15-30.
Crossref

 

Kunnumakkara AB, Shabnam B, Girisa S, Harsha C, Banik K, Devi TB, Choudhury R, Sahu H, ParamaD, Sailo B, Thakur KK, GuptaSC, Aggarwal BB. (2020). Inflammation, NF-kB, and chronic diseases: how are they linked? Critical Review of Immunology 40(1):1-39.
Crossref

 

Letsyo E, Jerz G, Winterhalter P, Beuerle T (2017). Toxic pyrrolizidine alkaloids in medicines commonly used in Ghana. Journal of Ethnopharmacology 202:154-161.
Crossref

 

Li Y, Zhao Y, Li G, Wang J, Li W, Lu J (2007). Regulation of neuronal nitric oxide synthase exon 1f gene expression by nuclear factor-kappaB acetylation in human neuroblastoma cells. Journal of Neurochemistry 101(5):1194-1204.
Crossref

 

Liu T, Zhang L, Joo D, Sun S-C (2017). NF-kB signaling in inflammation. Signal Transduction and Targeted Therapy 2:17023.
Crossref

 

Macedo T, Ribeiro V, Oliveira AP, Pereira DM, Fernandes F, Gomes NGM, Araujo L, Valentao P, Andrade PB (2020). Anti-inflammatory properties of Xylopia aethiopica leaves: Interference with pro-inflammatory cytokines in THP-1-derived macrophages and flavonoid profiling. Journal of Ethnopharrmacolgy 248:112312.
Crossref

 

Mbiantcha M, Almas J, Atsamo AD, Ateufack G, Shabana SU, Tatsinkou DF, Yousseu Nana W, Nida D (2018). Anti-inflammatory and anti-arthritic effects of methanol extract of the stem bark of Boswellia dalzielli Hutch (Burseraceae). Inflammopharmacology 26(6):13383-1398.
Crossref

 

Moon J-K, Shibamoto T (2009). Antioxidant assays for plant and food components. Agriculture and Food Chemistry 57(5):1655-1666.
Crossref

 

Moukette BM, Pieme CA, Nya Biapa PC, Ngogang JY (2015). In vitro antioxidant and anti-lipoperoxidative activities of bark extracts of Xylopia aethiopica against ion-mediated toxicity on liver homogenates. Journal of Complementary and Integrative Medicine 12(3):195-204.
Crossref

 

Mounanga MB, Mewono L, Angone SA (2015). Toxicity studies of medicinal plants used in sub-Saharan Africa. Journal of Ethnopharmacology 174:618-627.
Crossref

 

National Research Council (2008). "Marula" in Lost Crops of Africa: Volume III: Fruits. Lost Crops of Africa 3 Washington, DC. National Academies Press P 117.

 

Odugbemi T (2006). Outlines and Pictures of Medicinal Plants from Nigeria., University of Lagos Press.

 

Ojewole JA, Mawoza T, Chiwororo WD, Owira PM (2010). Sclerocarya birrea (A. Rich) Hochst. ['Marula'] (Anacardiaceae): A review of its phytochemistry, pharmacology and toxicology and its ethnomedicinal uses. Phytotherapy Research 24(5):633-639.
Crossref

 

Ojewole JAO (2003). Evaluation of the anti-inflammatory properties of Sclerocarya birrea (A.Rich.) Hochst. (family: Anacardiaceae) stem-bark extracts in rats. Journal of Ethnopharmacology 85(2-3):217-220.
Crossref

 

Orlando RA, Gonzales AM, Hunsaker LA, Franco CR, Royer RE, Vander Jagt DL, VanderJagt DJ (2010). Inhibition of nuclear factor kB activation and cyclooxygenase-2 expression by aqueous extracts of Hispanic medicinal herbs. Journal of Medicinal Food 13(4):888-895.
Crossref

 

Otimenyin SO, Uguru MO, Auta A (2008). Anti-inflammatory and analgesic activities of Cassia goratensis and Sarcocephalus esculentus extracts. Journal of Herbs, Spices and Medicinal Plants 13(2):59-67.
Crossref

 

Oyebode O, Kandala NB, Chilton PJ, Lilford RJ (2016). Use of traditional medicine in middle-income countries: a WHO-SAGE study. Health Policy Plan 31(8):984-991.
Crossref

 

Qin S, Hou D-X (2016). Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals. Molecular Nutrition Food Research 60(8):1731-1755.
Crossref

 

Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999). Antioxidant activity applying an improved ABTS radical cation decolonization assay. Free Radical Biology and Medicine 26(9-10):1231-1237.
Crossref

 

Saidu K, Onah J, Orisadipe A, Olusola A, Wambebe C, Gamaniel K (2000). Antiplasmodial, analgesic, and anti-inflammatory activities of the aqueous extract of the stem bark Erythrina senegalensis. Journal of Ethnopharmacology 71(1-2):275-280.
Crossref

 

Schleiser K, Harwat M, Bohm V, Bitsch R (2002) Assessment of antioxidant activity by using different in vitro methods. Free Radical Research 36(2):177-187.
Crossref

 

Schutze S, Machleidt T, Kronke M (1992). Mechanisms of tumor necrosis factor action. Seminars in Oncology 19(2 suppl 4):16-24.

 

Shaikh SB, Prabhu A, Bhandary YP (2019). Interleukin-17A a potential therapeutic target in chronic lung diseases. Endocrine, Metabolic &Immune Disorders- Drug Targets 19(7):921-928.
Crossref

 

Silberberg M, Morand C, Mathevon T, Besson C, Manach C, Scalbert A, Remesy C (2006). The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites. European Journal of Nutrition 45(2):88-96.
Crossref

 

Sivandzade F, Prasad S, Bhalerao A, Cucullo L (2019). Nrf2 and NF-kB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches. Redox Biology 21:101059.
Crossref

 

Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M (2006). Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Alternative Medicine Review 11(2):128-150.

 

Szymczak-Pajor I, Kleniewska P, Wieczfinska J, Pawliczak R (2020) Wide-range effects of 1,25(OH)2D3 on group 4A phospholipases is related to nuclear factor k-B and phospholipase-A2 activating protein activity in mast cells. International Archives of Allergy and Immunology 181(1):56-70.
Crossref

 

Talhouk RS, Karam C, Fostok S, El-Jouni W, Barbour EK (2007). Anti-inflammatory bioactivities in plant extracts. Journal of Medicinal Food 10(1):1-10.
Crossref

 

Tanih NF, Ndip RN (2012). Evaluation of the acetone and aqueous extracts of mature stem bark of Sclerocarya birrea for antioxidant and antimicrobial properties. Evidence-Based Complementary and Alternative Medicine 834156.
Crossref

 

Togola A, Diallo D, Dembele S, Barsett H, Paulsen BS (2005). Ethnopharmacological survey of different uses of seven medicinal plants from Mali, (West Africa) in the regions Doila, Kolokani and Silby. Journal of Ethnobiology and Ethnomedicine 1:7.
Crossref

 

Tropical Plants Database (2020). Ken Fern.tropical. the ferns.info. 2020-02-03.

View

 

Tsalamandris S, Antonopoulos AS, OIkonomou E, Papamikroulis GA, Vogiatzi G, Papaioannoou S, Deftereos S, Tousoulis D (2019). The role of inflammation in diabetes: Current concepts and future perspectives. European Cardiology Review 14(1):50-59.
Crossref

 

Unwin N, Albert KG. (2006). Chronic non-communicable diseases. Annals of Tropical Medicine and Parasitology 100(5-6):455-64.
Crossref

 

Valdivia-Correa B, Gomez-Guttierrez C, Uribe M, Mendez-Sanchez N. (2016). Herbal Medicine in Mexico: a cause of hepatotoxicity, A critical review. International Journal of Molecular Sciences 17(2):235-244.
Crossref

 

Wakawa HY, Hauwa M (2013). Protective effect of Erythrina senegalensis (DC) leaf extract on carbon tetrachloride-induced liver injury in rats. Asian Journal of Biological Science 6(4):234-238 (20130501).
Crossref

 

Wang Y, Xu J, Meng Y, Adcock IM, Yao X (2018). Role of inflammatory cells in airway remodeling in COPD. International Journal of Chronic Obstructive Pulmonary Disease 13:3341-3348.
Crossref

 

World Health Organization (WHO) (2018).

View

 

World Health Organization (WHO) (2019) WHO global Report on traditional and complementary medicine.

View

 

Xu P, Huecksteadt TP, Hoidal JR (1996). Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH). Genomics 34:173-180.
Crossref