This study was carried out in order to evaluate the antibacterial and antifungal activity of propolis and nanopropolis, against Staphylocuccus aureus and Candida albicans collected from Ferula ovina (Boiss.) Taleghan, Iran. Agar well diffusion method was employed to determine the antimicrobial activity of propolis and nanopropolis. The nanopropoils was prepared by milling media method. Most of the nanopropolis size was under the 100 nanometers. There were significant differences between propolis and nanopropolis in inhibition of S. aureus and C. albicans (p < 0.001 and p < 0.05), respectively. Findings of this study indicated that natural nanoparticles have the potential to be used efficiently in the control of bacterial and fungal diseases.
Key words: Nanopropolis, propolis, antimicrobial, Staphylococcus aureus, Candidaalbicans.
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