African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5088

Full Length Research Paper

Anti-quorum sensing and anti-biofilm activities of Securidaca longepedunculata Fresen, an endangered species from Burkina Faso

Issa Karama
  • Issa Karama
  • Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.
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Vincent Ouedraogo
  • Vincent Ouedraogo
  • Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.
  • Google Scholar
Ablassé Rouamba
  • Ablassé Rouamba
  • Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.
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Moussa Compaoré
  • Moussa Compaoré
  • Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.
  • Google Scholar
Martin Kiendrebeogo
  • Martin Kiendrebeogo
  • Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.
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  •  Received: 19 October 2020
  •  Accepted: 19 February 2021
  •  Published: 31 March 2021

Abstract

The emergence of bacterial resistance to antibiotics is a serious challenge to the global health system. The QS inhibition is one of the approaches to fight against antibiotic resistance in bacteria. Securidaca longepedunculata is a medicinal plant that roots are the only organ used against microbial diseases. This species is threatened with extinction due to the massive use of its roots in phytotherapy. In this study, the anti-QS and anti-biofilm activities of S. longepedunculata leaves methanolic extract at 100 to 400 µg/mL was assessed against the bacterial strains Chromobacterium violaceum CV026 and Pseudomonas aeruginosa PAO1. The results showed anti-QS and anti-biofilm activity of S. longepedunculata leaves which reduced violacein production in C. violaceum CV026 by 12 to 59%. The virulence factor pyocyanin in P. aeruginosa PAO1 was inhibited from 13 to 46%. Biofilm formation was significantly inhibited (41%) at 400 µg/mL.

 

Key words: Securidaca longepedunculata, anti-quorum, anti-biofilm.