Abstract

Cefepime is a fourth generation cephalosporin having an extended spectrum of activity against gram positive and gram negative bacteria. Sulbactam is a β-lactamase inhibitor similar in structure to clavulanic acid. In presence of sufficient β-lactamase inhibitor, the β-lactamase enzymes are neutralized and thus the drug used in combination with inhibitor has an opportunity to be more bactericidal and is of therapeutic value in treatment of certain microbial infections. This study was aimed at evaluating microbial efficacy of Supime, a fixed dose combination (FDC) of Cefepime and Sulbactam, in comparison with cefepime alone. Efficacy was evaluated on the basis Antibiotic Susceptibility Test (AST), Minimum Inhibitory Concentration (MIC) and Time Kill Curve (TKC) analysis in Staphylococcus aureus, Proteus mirabilis, Klebsiella pneumoniae and Enterobacter cloacae. In all organisms under study, Supime was found to have more bacterial inhibiting properties than cefepime in vitro.

Key words: Cefepime, sulbactam, supime, minimum inhibitory concentration.