African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5169

Full Length Research Paper

Antioxidant and nitric oxide status in patients diagnosed with Echinococcus granulosus

  Eser Kilic1, Süleyman Yazar2, Gülden BaÅŸkol1, Tarik ArtiÅŸ3 and Dilara Ersayit1  
  1Department of Biochemistry, Medical Faculty, Erciyes University, 38039-Kayseri/Turkey. 2Department of Parasitology, Medical Faculty, Erciyes University, 38039-Kayseri/Turkey. 3Department of General Surgery, Medical Faculty, Erciyes University, 38039-Kayseri/Turkey.
Email: [email protected]

  •  Accepted: 26 October 2010
  •  Published: 18 November 2010

Abstract

 

In the present study, we tried to investigate whether infection with cystic echinococcosis provokes oxidative stress in the host by measuring changes in plasma levels of anti-oxidants enzymes. 23 patients and 25 control individuals were included in the study. Plasma superoxide dismutase [Cu–Zn superoxide dismutases, cytoplasmic form/superoxide dismutase 1] and glutathione peroxidase [Cytoplasmic gluthatione peroxidase 1] activities and plasma nitrite levels were all determined based on the colorimetric methods. Statistically significant decreased cytoplasmic glutathione peroxidase and superoxide dismutase activities with decreased nitric oxide production, which produce superoxide radical was found in patients with cystic echinococcosis. Correlation analysis and statistical evaluation together showed that there was a significant negative correlation between glutathione peroxidase and superoxide dismutase activities (p < 0.001) and also significant negative correlation between glutathione peroxidase activity and nitric oxide level (p < 0.001). In addition, there was a significant negative correlation observed between superoxide dismutase activity and nitric oxide level (p < 0.001). These results clearly indicate a decline in the response to oxidative stresses. It may also be concluded that a decrease in the nitric oxide level can be associated with the low stimulation of the cell mediated immune system.

 

Key words: Cystic echinococcosis, superoxide dismutase, glutathione peroxidase, nitric oxide.