Abstract

The aim of this study is to assess the possible risk factors of patients from whom were isolated microorganisms which were resistant to broad spectrum antibiotics so as to shed light on the measures that should be taken in hospitals and community. These patients were those admitted to Çan secondary care hospital between January, 2009 and November, 2010. The strains isolated from them were evaluated and compared with respect to extended spectrum beta lactamases (ESBL)-producing gram negative bacteria, MRSA and Enterococcus spp.  A total of 289 patients and their 338 isolated strains were included in the study. The patients with 72 ESBL- producing gram negative bacteria were compared with the patients with 224 non-ESBL-producing gram negative bacteria, and five patients with MRSA were compared with 19 patients with MSSA. The patients treated with vancomycin which is sensitive 18 Enterococcus spp. strains were evaluated descriptively. Hospitalization in the previous three months, underlying conditions, and usage of quinolones were found to be significant risk factors for infectionswith ESBL-producing organisms. Urinary system disorders or malformations, chronic renal failure and hospitalization in the previous three months were found to be risk factors for MRSA infection. It is most likely that hospitalization and underlying conditions contribute to the spread and increase of antimicrobial resistance rates at community and hospitals.

Key words: Drug resistance, antimicrobial, risk factor, community-acquired infections, extended spectrum beta lactamases (ESBL), methicillin-resistance for S.aureus (MRSA).