The effect of the administration of Astragalus mongholicus (AM) injection liquid on the immunity function in children with congenital heart disease (CHD) after undergoing cardiopulmonary bypass surgery was examined. Sixty-two children with congenital heart disease were randomly assigned to group B (untreated control, n=21) or C (n=19) and D (n=22) (2, or 4 mg/kg daily astragalus membranac injection liquid intravenously for 6 days after anesthesia induction after undergoing cardiopulmonary bypass surgery). Another 23 patients (group A) served as pre-operational control. Results showed that A. mongholicusinjection liquid can enhance serum immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), tumor necrosis factor alpha (TNF- ɑ), soluble vascular cellular adhesion molecules (sVCAM-1) and soluble intercellular adhesion molecule 1 (sICAM). It can be concluded that astragalus membranac injection liquid can improve the immunity function in children with CHD after undergoing cardiopulmonary bypass surgery.
Key words: Astragalus mongholicus injection liquid, cardiopulmonary bypass surgery, CHD, sVCAM.
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