Abstract

The effect of the administration of Astragalus mongholicus (AM) injection liquid on the immunity function in children with congenital heart disease (CHD) after undergoing cardiopulmonary bypass surgery was examined. Sixty-two children with congenital heart disease were randomly assigned to group B (untreated control, n=21) or C (n=19) and D (n=22) (2, or 4 mg/kg daily astragalus membranac injection liquid intravenously for 6 days after anesthesia induction after undergoing cardiopulmonary bypass surgery). Another 23 patients (group A) served as pre-operational control. Results showed that A. mongholicusinjection liquid can enhance serum immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), tumor necrosis factor alpha (TNF- É‘), soluble vascular cellular adhesion molecules (sVCAM-1) and soluble intercellular adhesion molecule 1 (sICAM). It can be concluded that astragalus membranac injection liquid can improve the immunity function in children with CHD after undergoing cardiopulmonary bypass surgery.

Key words: Astragalus mongholicus injection liquid, cardiopulmonary bypass surgery, CHD, sVCAM.