African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 4958

Full Length Research Paper

Effect of Astragalus mongholicus injection liquid on the immunity function in children with congenital heart disease (CHD) after undergoing cardiopulmonary bypass surgery

Li Tong1, She Shaoyi2, Zhang Ge3, and Huang Weizhe4*    
1Department of Paediatrics, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China. 2Department of Urology, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China. 3Departments of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. 4Department of Cardiac Pulmonary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China.  
Email: [email protected]

  •  Published: 16 January 2012

Abstract

The effect of the administration of Astragalus mongholicus (AM) injection liquid on the immunity function in children with congenital heart disease (CHD) after undergoing cardiopulmonary bypass surgery was examined. Sixty-two children with congenital heart disease were randomly assigned to group B (untreated control, n=21) or C (n=19) and D (n=22) (2, or 4 mg/kg daily astragalus membranac injection liquid intravenously for 6 days after anesthesia induction after undergoing cardiopulmonary bypass surgery). Another 23 patients (group A) served as pre-operational control. Results showed that A. mongholicusinjection liquid can enhance serum immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), tumor necrosis factor alpha (TNF- ɑ), soluble vascular cellular adhesion molecules (sVCAM-1) and soluble intercellular adhesion molecule 1 (sICAM). It can be concluded that astragalus membranac injection liquid can improve the immunity function in children with CHD after undergoing cardiopulmonary bypass surgery.

 

Key words: Astragalus mongholicus injection liquid, cardiopulmonary bypass surgery, CHD, sVCAM.

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