African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

blaKPC-2 and blaOXA-48 producing Klebsiella pneumoniae found in a Turkish hospital in the Balkans

Sebnem Bukavaz
  • Sebnem Bukavaz
  • Department of Medical Microbiology, Faculty of Medicine, Trakya University, Edirne, Turkey.
  • Google Scholar
Metin Budak
  • Metin Budak
  • Department of Biophysics, Faculty of Medicine, Trakya University, Edirne, Turkey.
  • Google Scholar
Aygül Dogan Celik
  • Aygül Dogan Celik
  • VM Medical Park Hospital, Kocaeli, Turkey.
  • Google Scholar


  •  Received: 12 March 2018
  •  Accepted: 17 April 2018
  •  Published: 28 April 2018

References

Aktas Z, Kayacan CB, Schneider I, Can B, Midilli K, Bauernfeind A (2008). Carbapenem-hydrolyzing oxacillinase, OXA-48, persists in Klebsiella pneumoniae in Istanbul, Turkey. Chemotherapy 54(2):101-106.
Crossref

 

Al-Zahrani IA, Bander AA (2018). The emergence of carbapenem-resistant Klebsiella pneumoniae isolates producing OXA-48 and NDM in the Southern (Asir) province, Saudi Arabia. Saudi Med. J. 39(1):23-30.
Crossref

 

Andrade LN, Vitali L, Gaspar GG, Bellissimo-Rodrigues F, Martinez R, Darini AL (2014). Expansion and evolution of a virulent, extensively drug-resistant (polymyxin B-resistant), QnrS1-, CTX-M-2-, and KPC-2-producing Klebsiella pneumoniae ST11 international high-risk clone. J. Clin. Microbiol. 52(7):2530-2535.
Crossref

 

Azap O, Otlu B, Yesilkaya A, Yakupogullari Y (2013). Detection of OXA-48-like Carbapenemase-Producing Klebsiella pneumoniae in a Tertiary Care Center in Turkey: Molecular Characterization and Epidemiology. Balkan Med. J. 30(2):259-260.
Crossref

 

Band VI, Satola SW, Burd EM, Farley MM, Jacob JT, Weissb DS (2018). Carbapenem-resistant Klebsiella pneumoniae exhibiting clinically undetected colistin heteroresistance leads to treatment failure in a murine model of infection. M. Bio. 9(2):e02448-17.
Crossref

 

Baran I, Aksu N (2016). Phenotypic and genotypic characteristics of carbapenem-resistant Enterobacteriaceae in a tertiary-level reference hospital in Turkey. Ann. Clin. Microbiol. Antimicrob. 6:15-20.
Crossref

 

Barguigua A, Zerouali K, Katfy K, El Otmani F, Timinouni M, Elmdaghri N (2015). Occurrence of OXA-48 and NDM-1 carbapenemase-producing Klebsiella pneumoniae in a Moroccan university hospital in Casablanca, Morocco. Infect. Genet. Evol. 31:142-148.
Crossref

 

Bassetti M, Nicolini L, Esposito S, Righi E, Viscoli C (2009). Current status of newer carbapenems. Curr. Med. Chem. 16(5):564-575.
Crossref

 

Bathoorn E, Tsioutis C, da Silva Voorham JM, Scoulica EV, Ioannidou E, Zhou K, Rossen JW, Gikas A, Friedrich AW, Grundmann H (2016). Emergence of pan-resistance in KPC-2 carbapenemase-producing Klebsiella pneumoniae in Crete, Greece: a close call. J. Antimicrob. Chemother. 71(5):1207-1212.
Crossref

 

Benouda A, Touzani O, Khairallah MT, Araj GF, Matar GM (2010). First detection of oxacillinase-mediated resistance to carbapenems in Klebsiella pneumoniae from Morocco. Ann. Trop. Med. Parasitol. 104(4):327-330.
Crossref

 

Ulu AC, Kurtaran B, Inal AS, Kömür S, Kibar F, Çiçekdemir HY, Bozkurt S, Gürel D, Kılıç F, Yaman A, Aksu HS (2015). Risk factors of carbapenem-resistant Klebsiella pneumoniae infection: a serious threat in ICUs. Medical Science Monitor: Int. Med. J. Exp. Clin. Res. 17(21):219-224.

 

Carrer A, Poirel L, Eraksoy H, Cagatay AA, Badur S, Nordmann P (2008). Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Antimicrob. Agents Chemother. 52(8):2950-2954.
Crossref

 

Carrer A, Poirel L, Yilmaz M, Akan OA, Feriha C, Cuzon G, Matar G, Honderlick P, Nordmann P (2010). Spread of OXA-48-encoding plasmid in Turkey and beyond. Antimicrob. Agents Chemother. 54(3):1369-1373.
Crossref

 

Centers for Disease Control and Prevention (CDC) (2017). Healthcare-associated Infections: Tracking CRE. Available at http://www.cdc.gov/hai/organisms/cre/TrackingCRE.html. Accessed 11 April 2018.

 

Chiu SK, Chan MC, Huang LY, Lin YT, Lin JC, Lu PL, Siu LK, Chang FY, Yeh KM (2017). Tigecycline resistance among carbapenem-resistant Klebsiella pneumoniae: Clinical characteristics and expression levels of efflux pump genes. PLoS One. 12(4):e0175140.
Crossref

 

Cizmeci Z, Aktas E, Otlu B, Acikgoz O, Ordekci S (2017). Molecular characterization of carbapenem- resistant Enterobacteriaceae yields increasing rates of NDM-1 carbapenemases and colistin resistance in an OXA-48- endemic area. J. Chemother. 29(6):344-350.
Crossref

 

Cuzon G, Naas T, Bogaerts P, Glupczynski Y, Huang TD, Nordmann P (2008). Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae isolate from Belgium. Antimicrob. Agents Chemother. 52(9):3463-3464.
Crossref

 

Daikos GL, Markogiannakis A (2011). Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenems? Clin. Microbiol. Infect. 17(8):1135-1141.
Crossref

 

Dortet L, Cuzon G, Ponties V, Nordmann P (2017). Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014. Euro Surveill. 22(6):1-9.
Crossref

 

Fattouh R, Tijet N, McGeer A, Poutanen SM, Melano RG, Patela SN (2016). What Is the Appropriate Meropenem MIC for Screening of Carbapenemase-Producing Enterobacteriaceae in Low-Prevalence Settings? Antimicrob. Agents Chemother. 60(3):1556-1560.
Crossref

 

Fursova NK, Astashkin EI, Knyazeva AI, Kartsev NN, Leonova ES, Ershova ON, Alexandrova IA, Kurdyumova NV, Sazikina YS, Volozhantsev NV, Svetoch EA, Dyatlov IA (2015). The spread The spread of blaOXA-48 and blaOXA-244 carbapenemase genes among Klebsiella pneumoniae, Proteus mirabilis and Enterobacter spp. isolated in Moscow, Russia. Ann. Clin. Microbiol. Antimicrob. 14(46):1-9.

 

Goren MG, Chmelnitsky I, Carmeli Y, Navon-Venezia S (2011). Plasmid-encoded OXA-48 in Escherichia coli from Israel. J. Antimicrob. Chemother. 66(3):672-673.
Crossref

 

Gulmez D, Woodford N, Palepou MF, Mushtaq S, Metan G, Yakupogullari Y, Kocagoz S, Uzun O, Hascelik G, Livermore DM (2008). Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss. Int. J. Antimicrob. Agents 31(6):523-526.
Crossref

 

Hammoudi D, Ayoub Moubareck C, Aires J, Adaime A, Barakat A, Fayad N, Hakime N, Houmani M, Itani T, Najjar Z, Suleiman M, Sarraf R, Karam Sarkis D (2014). Countrywide spread of OXA-48 carbapenemase in Lebanon: surveillance and genetic characterization of carbapenem-non-susceptible Enterobacteriaceae in 10 hospitals over a one-year period. Int. J. Infect. Dis. 29:139-144.
Crossref

 

Jin-Long Y, MSW, An-Chun C, Kang-Cheng P, Chuan-Feng L, Shu-Xuan D, (2008). A simple and rapid method for extracting bacterial DNA from intestinal microflora for ERIC-PCR detection. World J. Gastroenterol. 14(18):2872.
Crossref

 

Karabay O, Altindis M, Koroglu M, Karatuna O, Aydemir A, Erdem AF (2016). The carbapenem-resistant Enterobacteriaceae threat is growing: NDM-1 epidemic at a training hospital in Turkey. Ann. Clin. Microbiol. Antimicrob. 15:1-6.
Crossref

 

Kuskucu MA, Karakullukcu A, Ailiken M, Otlu B, Mete B, Aygun G (2016). Investigation of carbapenem resistance and the first identification of Klebsiella pneumoniae carbapenemase (KPC) enzyme among Escherichia coli isolates in Turkey: A prospective study. Travel Med. Infect. Dis. 14(6):572-576.
Crossref

 

Labarca J, Poirel L, Ozdamar M, Turkoglu S, Hakko E and Nordmann P (2014). KPC-producing Klebsiella pneumoniae, finally targeting Turkey. New Microbes and New Infections. 2(2):50-51.
Crossref

 

Li J, Zou MX, Wang HC, Dou QY, Hu YM, Yan Q, Liu WE (2016). An Outbreak of Infections Caused by a Klebsiella pneumoniae ST11 Clone Coproducing Klebsiella pneumoniae Carbapenemase-2 and RmtB in a Chinese Teaching Hospital. Chin. Med. J. (Engl). 129(17):2033-2039.
Crossref

 

Meletis G (2016). Carbapenem resistance: overview of the problem and future perspectives. Ther. Adv. Infect. Dis. 3(1):15-21.
Crossref

 

Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, Cornaglia G, Garau J, Gniadkowski M, Hayden MK, Kumarasamy K, Livermore DM, Maya JJ, Nordmann P, Patel JB, Paterson DL, Villegas MV, Wang H, Woodford N, Quinn JP (2013). Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. The Lancet Infect. Dis. 13(9):785-796.
Crossref

 

Nazik H, Aydin S, Albayrak R, Bilgi EA, Yildiz I, Kuvat N, Kelesoglu FM, Pakasticali N, Yilmaz F and Öngen B (2014). Detection and Spread of Oxa-48-Producing Klebsiella oxytoca Isolates in Istanbul,Turkey. Southeast Asian J. Trop. Med. Public Health. 45(1):123-129.

 

Pasteran F, Faccone D, Rapoport M, Veliz O, Guerriero L, Gomez S, Petroni A, Corso A (2012). Rapid dissemination of OXA-163 carbapenemase, an emerging OXA-48 variant, in species of Enterobacteriaceae in multiple hospitals from Argentina: multiples clones and detection issues. Abstr 22th Eur Congress Clin Microbiol Infect, London, United Kingdom.

 

Patel G, Bonomo R 2013 "Stormy waters ahead": global emergence of carbapenemases. Frontiers in microbiology. 4:48.
Crossref

 

Patel G, Huprikar S, Factor SH, Jenkins SG, Calfee DP (2008). Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect. Control Hosp. Epidemiol. 29(12): 1099-1106.
Crossref

 

Poirel L. Heritier C, Tolun V, Nordmann P (2004). Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 48(1):15-22.
Crossref

 

Ramana KV, Rao R, Sharada ChV, Kareem M, Reddy LR, Ratna Mani M (2013). Modified Hodge test: A useful and the low-cost phenotypic method for detection of carbapenemase producers in Enterobacteriaceae members. J. Nat. Sci. Biol. Med. 4(2):346-348.
Crossref

 

Sahin K, Tekin A, Ozdas S, Akin D, Yapislar H, Dilek AR, Sonmez E (2015). Evaluation of carbapenem resistance using phenotypic and genotypic techniques in Enterobacteriaceae isolates. Ann. Clin. Microbiol. Antimicrob. 14:44-49.
Crossref

 

Saidani M, Hammami S, Kammoun A, Slim A, Boutiba-Ben Boubaker I (2012). Emergence of carbapenem-resistant OXA-48 carbapenemase-producing Enterobacteriaceae in Tunisia. J. Med. Microbiol. 61(12):1746-1749.
Crossref

 

Sheng JF, Li JJ, Tu S, Sheng ZK, Bi S, Zhu MH, Shen XM, Li LJ (2012). blaKPC and rmtB on a single plasmid in Enterobacter amnigenus and Klebsiella pneumoniae isolates from the same patient. Eur. J. Clin. Microbiol. Infect. Dis. 31(7):1585-1591.
Crossref

 

Skalova A, Chudejova K, Rotova V, Medvecky M, Studentova V, Chudackova E, Lavicka P, Tamara Bergerova T, Jakubu V, Zemlickova H, Papagiannitsis CC, Hrabak J (2017). Molecular Characterization of OXA-48- Like-Producing Enterobacteriaceae in the Czech Republic and Evidence for Horizontal Transfer of pOXA-48-Like Plasmids. Antimicrob. Agents Chemother. 61(2):e01889-16.

 

Srinivasan R, Ellappan K, Narasimha HB (2015). Prevalence and characterization of NDM-1 and OXA-48 carbapenemase gene harboring Enterobacteriaceae in a tertiary care hospital, South India. Acad. J. 7(6):60-63.

 

Thomas CP, Moore LS, Elamin N, Doumith M, Zhang J, Maharjan S, Warner M, Perry C, Turton JF, Johnstone C, Jepson A, Duncan ND, Holmes AH, Livermore DM, Woodford N (2013). Early (2008-2010) hospital outbreak of Klebsiella pneumoniae producing OXA-48 carbapenemase in the UK. Int. J. Antimicrob. Agents. 42(6):531-536.
Crossref

 

Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL (2012). Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin. Microbiol. Rev. 25(4):682-707.
Crossref

 

US Food and Drug Administration (FDA). FDA Approved Drug Products. 

View

 

van Duin D, Cober E, Richter SS, Perez F, Kalayjian RC, Salata RA, Evans S, Fowler VG, Bonomo RA, Kaye KS (2015). Residence in Skilled Nursing Facilities Is Associated with Tigecycline Nonsusceptibility in Carbapenem-Resistant Klebsiella pneumoniae. Infect. Control Hosp. Epidemiol. 36(8):942-948.
Crossref

 

van Duin D, Doi Y (2017). The global epidemiology of carbapenemase-producing Enterobacteriaceae. Virulence 8(4):460-469.
Crossref

 

Wayne PA (2014). Clinical and Laboratory Standards Institute, Performance standards for antimicrobial susceptibility testing; twentyfourth informational supplement. CLSI document M100-24.

 

Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, Alberti S, Bush K, Tenover F (2001). Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 45(4):1151-1161.
Crossref

 

Yu F, Wang S, Lv J, Qi X, Guo Y, Tang YV, Kreiswirth BN, Wang L, Chen L (2017). Coexistence of Oxa-48-Producing Klebsiella pneumoniae and Escherichia coli in a Hospitalized Patient Who Returned from Europe to China. Antimicrob. Agents Chemother. 61(4):e02580-16.
Crossref