African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2156

Full Length Research Paper

Effects of methanolic tuber extract of Cyperus esculentus Linn (tiger nuts) on sub-acute liver damage in albino rats

Thelma Ebele Ihedioha
  • Thelma Ebele Ihedioha
  • Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria.
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Rita Ifeoma Odo
  • Rita Ifeoma Odo
  • Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria.
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Uwakwe Simon Onoja
  • Uwakwe Simon Onoja
  • Department of Nutrition and Dietetics, Faculty of Agriculture, University of Nigeria, Nsukka, Enugu State, Nigeria.
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Chinweike Emmanuel Chiwetalu
  • Chinweike Emmanuel Chiwetalu
  • Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria.
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John Ikechukwu Ihedioha
  • John Ikechukwu Ihedioha
  • Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria.
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  •  Received: 16 May 2019
  •  Accepted: 23 August 2019
  •  Published: 30 September 2019

Abstract

This study evaluated the effects of Cyperus esculentus methanolic tuber extract (CEME) on carbon tetrachloride (CCl4)-induced sub-acute liver damage in albino rats. Dried tubers of C. esculentus were pulverized and extracted by cold maceration, using 80% methanol. Thirty albino rats, randomly assigned to 6 groups (A–F) of 5 each were used for the study. Sub-acute liver damage was induced in Groups A-E rats using intra-peritoneal injections of CCl4. Group A was treated with distilled water placebo, while Groups B, C and D were treated with 200, 400 and 800 mg/kg CEME, respectively. Group E was treated with 100 mg/kg Silymarin and Group F was also given distilled water placebo. Treatment was done orally for 15 days, after which hepatocellular integrity and liver function were evaluated. Results showed that treatment with CEME (at all doses) led to significantly lower (p<0.05) serum alanine aminotransferase and aspartate aminotransferase activities, bilirubin levels and relative liver weight of the CEME-treated groups, when compared to Group A rats. It was concluded that administration of CEME as used in the study led to significant protection of hepatocellular integrity, enhancement of hepatic excretion of bilirubin and amelioration of CCl4-induced inflammatory enlargement of the liver.

Key words: Cyperus esculentus, methanolic tuber extract, hepatoprotection, liver damage.