Abstract

Castor Bean (Ricinus communis, Family Euphorbiaceae) ethanol extraction (CBE) possesses potent antifertility effect, but the absorption of it is limited. Therefore, this study was aimed to prepare CBE microparticles for targeted drug effect. Poly (toluene-2, 4-di-isocyanate and ethylene alcohol) (TDI-EA) microparticles loaded with CBE were prepared by Interracial polymerization, a semi-industrial technique capable of encapsulating fragile molecules maintaining their native properties. The effects of several parameters on the properties of the particles were investigated. Microparticles showed of CBE- TDI-EA microparticles following 200, 400 and 600 mg/kg with a content of 5 mg two mean diameters that were 4 and 120 μm, separately, which are suitable for their absorption. Entrapment efficiency of CBEM in TDI-EA microparticles was 98.3%. The drug efficiency ranged from 73.26 to 100% depending on the drug consumption. The optimal growth suppression of the Kunming strain female mice vital organs could be achieved by oral application CBE in 6 mg microparticles while the Control Group showed the normal growth of the vital organs and CBE at the same concentration in solution form could not suppress the growth of the vital organs to the same extent. Finally, a bioassay demonstrated that the in vivo CBE microparticles have a strong depression of fertility without significant adverse reaction.

Key words: Antifertility, castor bean extract, female mice, microencapsulation.