African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Long term treatment of fluexotine and buspirone on gastric mucosal integrity in rats

Gehad A. Abdel-Jaleel
  • Gehad A. Abdel-Jaleel
  • Department of Pharmacology, National Research Center, El-Bohoth St., Dokki, P. O. Box 12622, Cairo, Egypt.
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Nawal S. Gomaa
  • Nawal S. Gomaa
  • Department of Pharmacology, National Research Center, El-Bohoth St., Dokki, P. O. Box 12622, Cairo, Egypt.
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Azza A. Ali
  • Azza A. Ali
  • Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls)Al-Azhar University, Nasr city, Greater Cairo, Egypt.
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Enaiat Omara
  • Enaiat Omara
  • Department of Pathology, National Research Center, El-Bohoth St., Dokki, P. O.Box 12622, Cairo, Egypt.
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Ola A. Sharaf
  • Ola A. Sharaf
  • Department of Pharmacology, National Research Center, El-Bohoth St., Dokki, P. O. Box 12622, Cairo, Egypt.
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  •  Received: 14 April 2016
  •  Accepted: 07 July 2016
  •  Published: 22 September 2016

Abstract

The highly selective serotonin reuptake inhibitors are successful in the treatment of depression mood and anxiety disorders. The objective of this study is to investigate the effect of fluexotine and buspirone when given orally in three dose levels (5, 10 and 15 mg/ kg) not only for eight weeks on gastric lesions and oxidative markers in normal rats' mucosal integrity, but also for four weeks on gastric mucosal lesions in rats treated with indomethacin- induced ulcers. The results of this study showed that in normal rats, the administration of fluoxetine induced gastric lesions while buspirone caused no lesions. The indomethacin administration resulted in the development of gastric mucosal lesions. Furthermore, co-administration of fluoxetine and indomethacin enhanced the development of gastric mucosal lesions that were coupled with disturbance in antioxidant status. Buspirone, in contrast, significantly decreased the development of gastric mucosal lesions in rats treated with indomethacin. In conclusion, fluoxetine caused the development of gastric mucosal lesions and aggravate the effect of indomethacin to induce ulcer, however, buspirone had a protective effect that may be attributed to its antioxidant properties.

Key words: Fluoxetine, buspirone, peptic ulcer, indomethacin-induced ulcer, oxidative stress. 

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This article is published under the terms of the Creative Commons Attribution License 4.0

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