African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Assessment of antimalarial activity and proteomics analysis of Dioscorea membranacea Pierre.

Phunuch Muhamad
  • Phunuch Muhamad
  • Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University (Rangsit Campus), Pathumtani 12121, Thailand.
  • Google Scholar
Luxana Panrit
  • Luxana Panrit
  • Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University (Rangsit Campus), Pathumtani 12121, Thailand.
  • Google Scholar
Artitiya Thiengsusuk
  • Artitiya Thiengsusuk
  • Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University (Rangsit Campus), Pathumtani 12121, Thailand.
  • Google Scholar
Wanna Chaijaroenkul
  • Wanna Chaijaroenkul
  • Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani 12121, Thailand.
  • Google Scholar
Kesara Na-Bangchang
  • Kesara Na-Bangchang
  • Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani 12121, Thailand.
  • Google Scholar


  •  Received: 15 June 2018
  •  Accepted: 03 July 2018
  •  Published: 22 July 2018

References

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Itharat A (2010). Comparative biological activities of five Thai medicinal plants called Hua-Khao-Yen. Thai Journal of Pharmacology 32(1):327-331.

 

Itharat A, Hiransai P (2012). Dioscoreanone suppresses LPS-induced nitric oxide production and inflammatory cytokine expression in RAW 264.7 macrophages by NF-κB and ERK1/2 signaling transduction. Journal of Cellular Biochemistry 113(11):3427-3435.
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Itharat A, Plubrukarn A, Kongsaeree P, Bui T, Keawpradub N, Houghton PJ (2003). Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre. Organic Letter 5(16):2879-2882.
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Panthong S, Ruangnoo S, Thongdeeying P, Sriwanthana B, Itharat A (2014). Immunomodulatory activity of Dioscorea membranacea Pierre rhizomes and of its main active constituent Dioscorealide B. BMC Complementary and Alternative Medicine 14:403.
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Pinmai K, Hiriote W, Soonthornchareonnon N, Jongsakul K, Sireeratawong S, Tor-Udom S (2010). In vitro and in vivo antiplasmodial activity and cytotoxicity of water extracts of Phyllanthus emblica, Terminalia chebula, and Terminalia bellerica. Journal of the Medical Association of Thailand 93(Suppl 7):S120-6.

 

Rasoanaivo P, Deharo E, Ratsimamanga-Urverg S, Frappier F (2004). Guidelines for the Nonclinical Evaluation of the Efficacy of Traditional Antimalarials. In: Traditional Medicinal Plants and Malaria, CRC Press.

 

Rungsihirunrat K, Chaijaroenkul W, Siripoon N, Seugorn A, Thaithong S, Na-Bangchang K (2012). Comparison of protein patterns between Plasmodium falciparum mutant clone T9/94-M1-1(b3) induced by pyrimethamine and the original parent clone T9/94. Asian Pacific Journal of Tropical Biomedicine 2:66-69.
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Saekoo J, Dechsukum C, Graidist P, Itharat A (2010). Cytotoxic effect and its mechanism of dioscorealide B from Dioscorea membranacea against breast cancer cells. Journal of the Medical Association of Thailand 93 (12):S277-82.

 

Singh M, Mukherjee P, Narayanasamy K, Arora R, Sen SD, Gupta S, Natarajan K, Malhotra P (2009). Proteome analysis of Plasmodium falciparum extracellular secretory antigens at asexual blood stages reveals a cohort of proteins with possible roles in immune modulation and signaling. The Molecular and Cellular Proteomics 8(9):2102-2118.
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Tewtrakul S, Itharat A (2006). Anti-allergic substances from the rhizomes of Dioscorea membranacea. Bioorganic and Medicinal Chemistry 14(24):8707-8711.
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Tewtrakul S, Itharat A, Rattanasuwan P (2006). Anti-HIV-1 protease- and HIV-1 integrase activities of Thai medicinal plants known as Hua-Khao-Yen. Journal of Ethnopharmacology 105(1-2):312-315.
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Thiengsusuk A, Chaijaroenkul W, Na-Bangchang K (2013). Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine. Parasitology Research 112(4):1475-1481.
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Thongdeeying P, Itharat A, Umehara K, Ruangnoo S (2016). A novel steroid and cytotoxic constituents from Dioscorea membranacea Pierre against hepatocellular carcinoma and cholangiocarcinoma cells. Journal of Ethnopharmacology 194:91-97.
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World Health Organization (2017). World malaria report 2017 Geneva: World Health Organization. 

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