African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2204

Full Length Research Paper

Assessment of acute and sub-chronic toxicity of Camellia hakodae Ninh leaves aqueous extracts in experimental animals

Hong Hanh Nguyen
  • Hong Hanh Nguyen
  • Cardiovascular Center, E Hospital, 87-89 Tran Cung Street, Cau Giay District, Hanoi, Vietnam.
  • Google Scholar
Hoang Ngan Nguyen
  • Hoang Ngan Nguyen
  • Department of Pharmacology, Vietnam Military Medical University (VMMU), 160 Phung Hung Street, Ha Dong District, Hanoi, Vietnam.
  • Google Scholar
Van Cuong Truong
  • Van Cuong Truong
  • Department of Rehabilitation, Thanh Nhan Hospital, 42 Thanh Nhan Street, Hai Ba Trung District, Hanoi, Vietnam.
  • Google Scholar

  •  Received: 11 April 2020
  •  Accepted: 10 June 2020
  •  Published: 31 August 2020


Baum N, Dichoso CC, Carlton CE (1975). Blood urea nitrogen and serum creatinine. Physiology and interpretations. Urology 5:583-588.


Carol SA (1995). Acute, subchronic and chronic toxicology. In: Michael JD, Mannfred AH editors. CRC Handbook of Toxicology, CRC Press Inc.: Boca Raton, pp. 51-104.


Dybing E, Doe J, Groten J, Kleiner J, O Brien J, Renwich AG, Schlatter J, Steinberg P, Tritscher A, Walker R, Younes M (2002). Hazard characterization of chemicals in food and diet: Dose-response, mechanism, and extrapolation issues. Food Chemical and Toxicology 42:237-282.


Farrugia A (2010). Albumin usage in clinical medicine: Tradition or therapeutic? Transfusion Medicine Reviews 24:53-63.


He DY, Sai X, Wang N, Li X, Wang L, Xu Y (2018). Camellia euphlebia exerts its antidepressant-like effect via modulation of the hypothalamic-pituitary-adrenal axis and brain monoaminergic systems. Metabolic Brain Disease 33:301-312.


Huang LD, Li ZH, Lu F, Qin MQ, Luo YY (2013). Three decades of breeding Golden Camellia varieties in Nanning Golden Camellia Park. International Camellia Journal 45:101-104.


Litchfield JTJr, Wilcoxon E (1949). A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96:99-113.


Manh TD, Thang NT, Son HT, Thuyet DV, Trung PD, Tuan NV, Duc DT, Linh MT, Lam VT, Thinh NH, Phuong NTT, Do TV (2019). Golden Camellias: A review. Archives of Current Research International 16: 1-8.


Mukhtar H, Ahmad N (2000). Tea polyphenols: prevention of cancer and optimizing health. American Journal of Clinical Nutrition 71:1698S-1702S.


Nguyen TT, Tran VH, Pham GD, Ninh T, Hung NT, Hoang VD (2019). A new sexangularetin derivative from Camellia hakodae. Natural Product Communications 14:1-4.


Ninh T, Hakoda N (2009). Cac loai Tra cua Vuon Quoc gia Tam Dao, Vietnam National University Press, Hanoi, pp. 1-121.


OECD (1981). Test No: 411, Subchronic dermal toxicity: 90-day study. Section 2. 411. Paris: OECD Publishing, pp. 5-9.


OECD (1987). Test No: 402, Acute dermal toxicity. Section 2. 402. Paris: OECD Publishing, pp. 1-3.


OECD (2004). Test No: 434, Acute dermal toxicity - fixed-dose procedure Section 20 to 34. 434. Paris: OECD Publishing, pp. 4-5.


Van NTH, Inh CT, Bach PC, Tuyen TT, Thanh NT, Quynh NH, Long PQ (2018). Flavonoid glycoside isolated from Camellia chrysantha. Vietnam Journal of Chemistry 56:335-340.


Wedemeyer H, Hofmann WP, Lueth S, Malinski P, Thimme R, Tacke F, Wiegand J (2010). ALT screening for chronic liver diseases: Scrutinizing the evidence. Zeitschrift für Gastroenterologie 48:46-55.


Wei JB, Li X, Song H, Liang YH, Pan YZ, Ruan JX, Qin X, Chen YX, Nong CL, Su ZH (2015). Characterization and determination of antioxidant components in the leaves of Camellia chrysantha (Hu) Tuyama based on composition activity relationship approach. Journal of Food and Drugs Analysis 23:40-48.


Xu J, Wang M, Zhao J, Wang HD, Tang Q, Khan IA (2018). Yellow tea (Camellia sinensis L.), a promising Chinese tea: Processing, chemical constituents and health benefits. Food Research International 107:567-577.