African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2205

Table of Content: 15 April, 2016; 10(14)

April 2016

Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in mice brain after in vitro-induced oxidative stress

This study aimed to investigate the in vitro antioxidant activity of the novel anticonvulsant levetiracetam and benzodiazepine clonazepam. To do this, the mice brain homogenates were incubated with levetiracetam (50, 100 or 200 g/ml) or clonazepam (50, 100 or 200 g/ml), and then, submitted to heating at 37°C for 1 h. Ascorbic acid (vitamin C, 200 g/ml) was used as reference antioxidant drug. The markers of...

Author(s): Aline de Albuquerque Oliveira, Maria Isabel Linhares, Adriano José Maia Chaves Filho, Emiliano Ricardo Vasconcelos Rios, Camila Nayane de Carvalho Lima, Edith Teles Venancio, Alana Gomes de Souza, Klistenes Alves de Lima, Francisca Cléa Florenço de Sousa, Danielle Macedo Gaspar and Marta Maria de França Fonteles,

April 2016

Steady-state bioequivalence study of clozapine psychotic patients in Brazil

The present work aimed to compare the relative bioavailability of Zolapin with 100 mg tablet Leponex as a reference formulation, through a simple, robust and low-cost bioequivalence assays method. The study design was multiple-dose, randomized, crossover with patients in steady-state, and was performed with 24 schizophrenic male patients. Subjects received 100 mg twice a day of either Leponex or Zolapin for 10 days. At...

Author(s): Margareth de Oliveira Timóteo, Gutemberg Gomes Alves , Gilberto Perez Cardoso, Beni Olej, Mauro Vitor Mendlowicz, Luis Guillermo Coca Velarde and Luiz Querino de Araújo Caldas,

April 2016

In- vivo and vitro bioactivities of the essential oil of Duguetia lanceolata branches

The present study investigated the in- vivo and vitro bioactivities of the essential oil of Duguetia lanceolata branches (EODL) and caryophyllene oxide (CO). The chemical composition of EODL was analyzed by GC and GC/MS. Acetic acid-induced writhing, formalin, hot plate and tail-immersion methods were used to evaluate the antinociceptive effect in mice. Anti-inflammatory activity was tested by carrageenan-induced paw...

Author(s): Orlando Vieira de Sousa, Glauciemar Del-Vechio-Vieira, Bruna Celeida Silva Santos, Célia Hitomi Yamamoto, Ana Lúcia Santos de Matos Araújo, Ailson da Luz André de Araújo, Miriam Aparecida de Oliveira Pinto, Mirian Pereira Rodarte and Maria Silvana Alves