African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2241

Table of Content: 8 August, 2013; 7(29)

August 2013

Synergic effect of associated green, red and brown Brazilian propolis extract onto Streptococcus mutans and Streptococcus sanguinis

Propolis is an organotherapeutic product collected by honeybees and has relevant pharmacological properties, highlighting the high antimicrobial activity. This study aimed to evaluate in vitro the synergistic effect between three ethanol extract of different Brazilian propolis samples: green (Baccharis dracunculifolia) (A), red (Dalbergia ecastophyllum) (B) and brown (Copaifera sp) (C) propolis by...

Author(s): João Luís Duval Cândido da Silva, Fernando Freitas Silva, Thiago Fernandes Machado de Souza, Wellington Gomes Generoso, Vladimir Reimar Souza Noronha, Elizete Maria Rita Pereira , Mariana Passos De Luca,  Sheila Lemos Rago Abreu and Vagner Rodrigues Santos    

August 2013

Screening of the antioxidant, antimicrobial and DNA damage protection potentials of the aqueous bark extract of Pistachio nuts (Pistacia vera L.) from Turkey


Author(s): Seyda Berk and Bektas Tepe    

August 2013

Effects of omega-3 administration on concentration of serum inflammatory makers in renal transplant recipient

Omega-3 polyunsaturated fatty acids have been shown to decrease inflammatory markers such as TNF-α, IL-1ß and IL-6 levels. It has been shown that there is association between several markers of inflammation with cardiovascular disease which is the leading cause of death in the end stage of renal disease (ESRD) patients. So it may be useful to administer this supplement in renal transplant recipients. To...

Author(s): Amir Hooshang Mohammadpour, Fatemeh Nazemian, Jamal Shamsara, Maryam Bafandegan, Maryam Ghorbani and Seyed Adel Moallem    

August 2013

Evaluation of comparative free-radical scavenging capacity, and antioxidant activities of methanolic extracts of leaf, stem, and roots of Operculina turpethum

The aim of this study was to evaluate the free-radical scavenging capacity and antioxidant activity of methanolic extracts of Operculina turpethum leaves (MEOTL), stem (MEOTS), and roots (MEOTR) in vitro methods. The antioxidant activity was evaluated by reducing power, 2, 2- diphenyl-1-picrylhydrazyl radical (DPPH) photometric assay, nitric oxide free radical scavenging, iron chelation, hydrogen...

Author(s): Shankaraiah Pulipaka, Ravindra Babu Pingili, Nazima Farheen, Bandla Susan Showry Reddy and Haroled Peter Pathrose Leelabai    

August 2013

A change in metabolic status of glutathione (γ-L-glutamyl-2-cysteinyl-glycine) in lymphocytes by lead compounds

A spectrophotometric investigation of the interaction and coordination of lead compounds with glutathione (GSH) in lymphocytes of healthy male volunteer venous blood has been described. The present study was designed to provide insight into the proposed mechanism of action of lead acetate {Pb(CH3COO)2} and lead acetylacetonate (C10H14O4Pb) with GSH at molecular level. Lymphocytes were separated from blood of healthy...

Author(s): Naseem Ullah, Muhammad Farid Khan, Muhammad Mukhtiar, Haroon Khan, Asim.ur.Rehman    

August 2013

A comparative evaluation of the quality of ten generic telmisartan tablets with the brand

The objective of this study was to comparatively assess the quality of generic Telmisartan tablets with the brand. Mean drug content and impurities determination, dissolution tests and solubility tests in four different media were performed on ten Telmisartan generics and the brand Micardis. High performance liquid chromatography was used in the determination of Telmisartan content, impurities and solubility of...

Author(s): Bora Lichanda, , Mi Luo, , Hui Wang, , Qi Pei, and Bikui Zhang    

August 2013

Susceptibility of fish-associated Flavobacterium spp. isolates to cinnamaldehyde, vanillin and Kigelia africana fruit extracts

Phytochemicals are being explored as therapeutic alternatives in aquaculture since they have de-stressing, growth-promoting, appetite-increasing, immune-stimulating, and antimicrobial properties.  The susceptibility of 28 Flavobacterium johnsoniae-like isolates and nine selectedFlavobacterium spp. isolates to three phytochemicals, viz.: cinnamaldehyde (10 - 250 µg/ml), vanillin (5 - 500 µg/ml)...

Author(s): Hafizah Y. Chenia and Sarisha Singh    

August 2013

Bioassay guided isolation and characterization of anti-microbial and anti-trypanosomal agents from Berberis glaucocarpa Stapf.

Different fractions of Berberis glaucocarpa Stapf were tested for their antibacterial and anti-trypanosomal properties using the well established Alamar blueTM 96 well microplate assays. Then eight known compounds (1-8), including five alkaloids (1-5), were isolated and characterized from this plant for the first time. All the compounds were tested for their antimicrobial and antitrypanosomal properties....

Author(s): Muhammad Alamzeb, M. Rafiullah Khan, Saqib Ali, Mamoon-Ur-Rashid and Ashfaq Ahmad Khan    

August 2013

Reproductive, cytological and biochemical toxicity of fenugreek in male Swiss albino mice

Fenugreek was evaluated for its effects on reproductive, cytological and biochemical toxicity in mice. On the basis of evaluated maximum tolerated dose (MTD; 9.77 g/kg), the present doses selected for sub-chronic (90 days) treatment were 153, 305 and 610 mg/kg/day by oral gavage corresponding to 1/64, 1/32 and 1/16, of MTD, respectively. Total sperm count, motility and spermatozoa morphology was screened. Cytological...

Author(s): Abdulaziz A. Al-Yahya    

August 2013

Effects of traditional Chinese herbal medicines on blood cell count and immunity in chickens

To investigate the effects of traditional Chinese herbal medicines (TCHM) on hematological parameters and immunity in chickens, Astragalus membranaceus (AM), Angelicae sinensisextract (ASE) and Danggui Buxue San (DBS) were used for the study of immunity and hematinic mechanism in order to provide basis for clinical reference. Three hundred 56-week-old hens were randomized into 10 groups. AM were added...

Author(s): Chunhong Li, Yulong Dong, Haifeng Hou, Qian Li, Ruihua Zhang, Ruiling Qin, Zhonghao Li, Yongzhan Bao and Wanyu Shi    

August 2013

In vitro antimicrobial and anti-inflammatory activity of Jordanian plant extracts: A potential target therapy for Acne vulgaris

Acne vulgaris is a chronic inflammatory disorder in which Propionibacterium acnes plays a critical role in its development when it overgrows in the pilosebaceous unit.   The present study was conducted to evaluate the antimicrobial and anti-inflammatory activity of fourteen Mediterranean plant extracts separately and in combinations for the treatment of acne. The methanolic plant extracts were...

Author(s): Bassam I. Amro, Randa N. Haddadin, Khaled Tawaha, Mohammad Mohammad, Sundus Mashallah and Areej M. Assaf    

August 2013

Assessment of herbal anthelmintics used by the farmers in Kirinyaga county, Kenya, for the treatment of helminthiosis in cattle

The aim of this study was to assess and validate the herbal anthelmintic remedies used by farmers in Kirinyaga county, Kenya for the treatment of their cattle against gastrointestinal nematodes. The herbs used were identified via questionnaire surveys through focused group discussions. The aqueous extracts of plants used: Aspillia pluriseta, Vernonia lasiopus,Entada leptostachya and Erythrina...

Author(s): F. K. Njonge, M. Mutugi, P. G. Kareru, S. M. Githigia, R. Waihenya and W. O. Nyakundi    

August 2013

Production of lovastatin from rice straw using Aspergillus terreus in solid state fermentation

Responce surface methodology (RSM) was used to optimize  production of lovastatin from rice straw in solid state fermentation by Aspergillus terreus ATCC 74135. A four-factor-five-level central composite design (CCD) was used  to examine the combining effects of temprature, moisture, inoculum and pH on lovastatin production.  Results of the CCD study showed  that only temperature and...

Author(s): Mohammad Faseleh Jahromi, Liang Juan Boo, Ho Yin Wan, Rosfarizan Mohamad, Goh Yong meng and Parisa Shokryazdan    

August 2013

In vitro and in vivo antidiabetic effect of Andrographis lineata Wall. Ex.Nees and Andrographis serphyllifolia Wt.Ic leaf extracts

Andrographis lineata and Andrographis serphyllifolia are endemic potential medicinal plants of South India. The leaves of both the herbs have been used as ancient folklore medicine for curing diabetes, snakebite, inflammation and cancer. The present investigation deals with the study of in vitro and in vivo antidiabetic effect of the ethanolic leaf extract of A....

Author(s): V. Sudarshana Deepa, K. Rajaram, P. Suresh Kumar