Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3584

Full Length Research Paper

Antiviral effect of the seaweed Osmundaria obtusiloba against the Zika virus

Claudio Cesar Cirne-Santos
  • Claudio Cesar Cirne-Santos
  • Laboratório de Virologia Molecular e Biotecnologia Marinha, Programa de Pós-graduação em Ciências e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense 24020-141, RJ, Brasil.
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Caroline de Souza Barros
  • Caroline de Souza Barros
  • Laboratório de Virologia Molecular e Biotecnologia Marinha, Programa de Pós-graduação em Ciências e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense 24020-141, RJ, Brasil.
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Caio Cesar Richter Nogueira
  • Caio Cesar Richter Nogueira
  • Laboratório de Virologia Molecular e Biotecnologia Marinha, Programa de Pós-graduação em Ciências e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense 24020-141, RJ, Brasil.
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Leonardo dos Santos Correa Amorim
  • Leonardo dos Santos Correa Amorim
  • Laboratório de Virologia Molecular e Biotecnologia Marinha, Programa de Pós-graduação em Ciências e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense 24020-141, RJ, Brasil.
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Renata de Mendonca Campos
  • Renata de Mendonca Campos
  • Instituto de Microbiologia, Departamento de Virologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
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Norman Arthur Ratcliffe
  • Norman Arthur Ratcliffe
  • Department of Biociences, College of Science Swansea University, SA2 8PP. UK.
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Valeria Laneuville Teixeira
  • Valeria Laneuville Teixeira
  • Laboratório Algamar, Departamento de Biologia Marinha, Instituto de Biologia, Universidade Federal Fluminense 24020-141, RJ, Brasil.
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Davis Fernandes Ferreira
  • Davis Fernandes Ferreira
  • Instituto de Microbiologia, Departamento de Virologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
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Izabel Christina Nunes de Palmer Paixao
  • Izabel Christina Nunes de Palmer Paixao
  • Laboratório de Virologia Molecular e Biotecnologia Marinha, Programa de Pós-graduação em Ciências e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense 24020-141, RJ, Brasil.
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  •  Received: 13 June 2018
  •  Accepted: 30 July 2018
  •  Published: 10 October 2018

Abstract

Zika virus (ZIKV), a mosquito-borne member of the family Flaviviridae, is a human pathogen of global significance. Recently, ZIKV, has become a public health problem with increases in numbers of cases and a strong association between ZIKV outbreaks and the spread of cases of Guillain-Barré Syndrome and microcephaly. In this study, the extracts of the seaweed Osmundaria obtusiloba (O. obtusiloba) (native to the Brazilian coast) against ZIKV using Vero cells was evaluated. The seaweed extract tested inhibited ZIKV replication in a dose-dependent manner at low concentrations with EC50 values of 1.82 μg/mL and a selective index (SI) of 288. Other results showed that this extract had significant virucidal effects. In addition, when the extract and Ribavirin were used concomitantly there was a significant synergistic effect. Our promising results suggest that extracts of O. obtusiloba are excellent candidates for further studies, and that marine algae are potentially important sources for the development of novel anti-ZIKV agents.

Key words: ZIKA, seaweeds, antiviral activity, marine algae, Osmundaria obtusiloba.