Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3840

Full Length Research Paper

In vitro cytotoxic potential of Yacon (Smallanthus sonchifolius) against HT-29, MCF-7 and HDFn cell lines

Rachelle P. Mendoza
  • Rachelle P. Mendoza
  • Center for Biopharmaceutical Research, De La Salle Health Sciences Institute, Malate, Manila, Philippines.
  • Google Scholar
Warren S. Vidar
  • Warren S. Vidar
  • Department of Chemistry, College of Humanities and Sciences, De La Salle Health Sciences Institute, Malate, Manila, Philippines.
  • Google Scholar
Glenn G. Oyong
  • Glenn G. Oyong
  • Department of Biology, College of Science, Center for Natural Sciences and Environmental Research, De La Salle University, Malate, Manila, Philippines.
  • Google Scholar


  •  Received: 27 July 2016
  •  Accepted: 06 March 2017
  •  Published: 10 March 2017

References

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Genta SB, Cabrera WM, Mercado MI, Grau A, Catalán CA, Sánchez SS (2010). Hypoglycemic activity of leaf organic extracts from Smallanthus sonchifolius: constituents of the most active fractions. Chem. Biol. Interact.185:143-152.
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Ishikawa T, Hyakutake T, Gondou Y, Sakai M, Kinoshita R, Tottori, J, Kunitake H, Kusumoto KI (2010). Anti-Melanogenic Activity of Yacon Leaves in Mouse Melanoma Cells. Anim. Cell Technol: Basic Appl. Aspects 16:359-364.
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Min KJ, Cheon JU, Cha CG (2012). Anti-oxidative and Anti-cancer Activities of Extracting of Yacon. Korean J. Food Sci. Anim. Resour. 32(2):190-197.

 
 

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Ornelas G, Oliveira C, Bragab P, Fernandes AAH (2013). Improvement of biochemical parameters in type 1 diabetic rats after the roots aqueous extract of yacon [Smallanthus sonchifolius (Poepp. & Endl.)] treatment. Food Chem. Toxicol. 59:256-260.
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Padla EP, Solis LT, Ragasa CY (2012). Antibacterial and antifungal properties of ent-kaurenoic acid from Smallanthus sonchifolius. Chin. J. Nat. Med. 10(6):408-414.
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Pedreschi R, Campos D, Noratto G, Chirinos G, Cisneros-Zeval (2003). Andean yacon root (Smallanthus sonchifolius Poepp. & Endl.) Fructooligosaccharides as a potential novel source of prebiotics. J. Agric. Food Chem. 51:5278-84.
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Raga DD, Alimboyoguen AB, del Fierro RS, Ragasa CY (2010). Hypoglycemic effects of tea extracts and ent-kaurenoic acid from Smallanthus sonchifolius. Nat. Prod. Res. 24(18):1771-1782.
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Riss TL, Moravec RA, Niles AL, Duellman S, Benink HA, Worzella T, Minor L (2013). Cell Viability Assays. In: Assay Guidance Manual; Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Bejcek B, Glicksman M, Inglese J, Iversen PW, Li Z, McGee J, McManus O, Minor L, Napper A, Peltier JM, Riss T, Trask OJ Jr, Weidner J (eds,). Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences. Available at: 

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Sankara A, Naresh J, Kumar L, Mokkapati A (2013). In vitro anti-cancer activities of few plant extracts against MCF-7 and HT-29 cell lines. Int. J. Pharm. Sci. 3(2):185-188. Cite author name in body of work.

 
 

Siriwan D, Miyawaki C, Miyamoto T, Naruse T, Okazaki K and Tamura H (2011). Chemopreventive Activity of Sesquiterpene Lactones (SLs) from Yacon against TPA-induced Raji Cells Deformation. Pak. J. Biol. Sci. 14:605-609.
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Siriwan D, Naruse T, Tamura H (2011). Effect of epoxides and [α]-methylene-[γ]-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and nf-[κ]b inhibition in human cervical cancer cells. Fitoterapia 10:10-16.

 
 

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Valentova K, Lebeda A, Dolezalová I, Jirovský D, Simonovska B, Vovk I, Kosina P, Gasmanová N, Dziechciarková M, Ulrichová J (2006). The biological and chemical variability of yacon. J. Agric. Food Chem. 54(4):1347-52.
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Valentova K, Ulrichová J (2003). Smallanthus sonchifolius and Lepidium meyenii - prospective Andean crops for the prevention of chronic diseases. Biomed Pap Med. Fac. Univ. Palacky Olomouc Czech Repub. 147(2):119-30.
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Velez E, Castillo N, Mesón O, Grau A, BibasBonet ME, Perdigón G (2013). Study of the effect exerted by fructooligosaccharides from yacon (Smallanthus sonchifolius) root flour in an intestinal infection model with Salmonella typhimurium. Br. J. Nutr. 109(11):1971-9.
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