Journal of
Toxicology and Environmental Health Sciences

  • Abbreviation: J. Toxicol. Environ. Health Sci.
  • Language: English
  • ISSN: 2006-9820
  • DOI: 10.5897/JTEHS
  • Start Year: 2009
  • Published Articles: 208

Full Length Research Paper

Comparative nephrotoxic effect associated with exposure to diesel and gasoline vapours in rats

F. E. Uboh1*, M. I. Akpanabiatu2, J. I. Ndem2, Y. Alozie3 and P. E. Ebong1
1Department of Biochemistry, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria. 2Department of Biochemistry, College of Medical Sciences, University of Uyo, Uyo, Akwa Ibom State, Nigeria. 3Department of Biochemistry, Cross River State University of Technology, Calabar, Nigeria.
Email: [email protected]

  •  Accepted: 01 December 2009
  •  Published: 31 December 2009

Abstract

Comparative effect of exposure to 20.7 ± 5.8 cm3 h-1kg-1m-3 day-1 of diesel and gasoline vapours on the
kidney functions was assessed in rats. It was observed that exposure to diesel and gasoline vapours
produced a significant increase (P < 0.05) in serum creatinine, urea, BUN, uric acid, glucose and K+; and
a significant decrease (P < 0.05) in serum Na+ and Cl- levels. However, the percentage increase in serum
creatinine, urea, BUN, uric acid, glucose, K+; and decrease in serum Na+ and Cl- levels recorded for the
rats exposed to diesel vapour were significantly higher (P < 0.05) compared to the percentages
recorded for rats exposed to gasoline vapour. The result of this study indicates that exposure to diesel
and gasoline vapours may be a risk factor for nephrotoxicity in rats; and that diesel vapour tends to
contain chemical substance(s) that are more nephrotoxic than gasoline vapour.
Key words: Diesel, gasoline, creatinine, urea, electrolytes, nephrotoxicity.