Journal of
Toxicology and Environmental Health Sciences

  • Abbreviation: J. Toxicol. Environ. Health Sci.
  • Language: English
  • ISSN: 2006-9820
  • DOI: 10.5897/JTEHS
  • Start Year: 2009
  • Published Articles: 200

Full Length Research Paper

Ameliorative role of quercetin in iron overload induced heart and brain toxicity in adult male albino rats

El-Sayed Eman H. K.
  • El-Sayed Eman H. K.
  • Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Egypt.
  • Google Scholar
Zeinab Abdou Mohammed
  • Zeinab Abdou Mohammed
  • Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Egypt.
  • Google Scholar
Mona Mostafa Ahmed
  • Mona Mostafa Ahmed
  • Pathology Department, Faculty of Medicine, Zagazig University, Egypt.
  • Google Scholar


  •  Received: 02 January 2019
  •  Accepted: 04 February 2019
  •  Published: 28 February 2019

References

Abd El-Baky A, Abdullah A, Abd-El Hay E (2009). Amelioration of iron-overload adverse effect by iron chelator in rats. Journal of Applied Sciences Research 5:1155-1162.

 

AbdElkader A, Aly F (2015). Protective Effect of Melatonin Against Iron Overload-Induced Toxicity In Rats. International Journal of Pharmacy and Pharmaceutical Sciences 7(9):116-121.

 

Ahmadi M, Dehghan G, Hosseinpourfeizi A, Dolatabadi N, Kashanian S (2011). Preparation, characterization, and DNA binding studies of water-soluble quercetin–molybdenum (VI) complex. DNA and Cell Biology 30(7):517-523.
Crossref

 

Ali M, Gomaa M, Shalby S, Mohammed Z (2017). Study of chronic toxic effect of deltamethrin and dimethoate on brain of adult male albino rats. Zagazig Journal of Forensic Medicine 15(1):29-46.
Crossref

 

Anderson J (2007). Mechanisms of iron loading and toxicity. American Journal of Hematology 82:1128-1131.
Crossref

 

Ayer A, Mario M, Sandro A (2014). Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal Oxidative. Med. Cell. Longevity, Article ID 360438, 31.

 

Baccan M, Chiarelli-Neto O, Pereira S, Espósito P (2012). "Quercetin as a shuttle for labile iron," Journal of Inorganic Biochemistry 107(1):34-39.
Crossref

 

Bancroft D, Stevens A (1996). Theory and Practice of Histological Techniques. (4thEd.).Churchill Livingstone Press, Edinburgh, London, Melbourne, New York pp. 99-112.

 

Barcelos R, Grotto D, Serpelon M, Angeli P, Rocha A, de Oliveira Souza C, Vicentini T, Emanuelli T, Bastos K, Antunes M, Knasmüller S, Barbosa J (2011). Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats. Archives of Toxicology 85:1151-1157.
Crossref

 

Berdoukas V, Nord A, Carson S, Puliyel M, Hofstra T, Wood J, Coates D (2013). Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age. American Journal Of Hematology 88:283-285.
Crossref

 

Beutler E (2006). Hemochromatosis: genetics and pathophysiology. Annual Review of Medicine 57:331-347.
Crossref

 

Bu T, Mi Y, Zeng W, Zhang C (2011). Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice. Anatomical Record 294:520-526.
Crossref

 

Bureau G, Longpre F, Martinoli G (2008). Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. Journal of Neuroscience Research 86:403-410.
Crossref

 

Chan T, Lin C, Chuang H, Shiau J, Liao W, Yeh L (2014). "Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte Dna Damage and Plasma Lipid Peroxidation Induced by Tsa in Vivo," BioMed Research International.
Crossref

 

El-Maraghy A, Rizk M, El-Sawalhi B (2009). Hepatoprotective potential of crocin and curcumin against iron overload-induced biochemical alterations in rat. African Journal of Biochemistry Research 3:215-221.

 

El-Nekeety A, Abdel-Azeim H, Hassan M, Hassan S, Aly E, Abdel-Wahhab A (2014). "Quercetin inhibits the c ytotoxicity and oxidative stress in liver of rats fed aflatoxin-contaminated diet," Toxicology Reports 1:319-329.
Crossref

 

Elseweidy M, Abd El-Baky E (2008). Effect of dietary iron overload in rat brain: oxidative stress, neurotransmitter level and serum metal ion in relation to neurodegenerative disorders. Indian Journal of Experimental Biology 46(12):855-858.

 

El-Sheikh A, Ameen H, AbdEl-Fatah S (2018). Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine. International Journal of Toxicology 2018.
Crossref

 

Fairbairn W, Olive L, O'Neill L (1995). The comet assay: A comprehensive review. Mutation Research 339:37-59.
Crossref

 

Frey A, Reed H (2012). The ubiquity of iron. ACS Chemical Biology 7:1477-1481.
Crossref

 

Gerates L, Moonen J, Brauers K, Wouters M, Bast A, Hageman J (2007). Dietary flavones and flavonols are inhibitor of poly (ADP-ribose) polymerase-1 in pulmonary epithelial cells. Journal of Nutrition 137:2190-2195.
Crossref

 

Gholampour F, Ghiasabadi B, Owji M, Vatanparast J (2017). The protective effect of hydroalcoholic extract of Ginger (Zingiber officinale Rosc.) against iron-induced functional and histological damages in rat liver and kidney. Avicenna Journal of Phytomedicine 7(6):542-553.

 

Goodman S, Gilman A (2006). The Pharmacological Basis of Therapeutics.11th edition. New York: McGraw-Hill.

 

Halliwell B, Gutteridge M (1990). Role of free radicals and catalytic metal ions in human disease: An overview.Methods in Enzymology186: 1-85.
Crossref

 

Hametner S, Wimmer I, Haider L, Pfeifenbring S, Br€uck W, Hans H (2013). Iron and Neurodegeneration in the Multiple Sclerosis Brain. Annals of Neurology 74(6):1-14.
Crossref

 

Horniblow D, Henesy D, Iqbal H, Tselepis C (2017). Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro. Molecular nutrition and food research 61(3):1600692.
Crossref

 

Horta N, Kahl F, Sarmento S, Nunes S, Maglione R, Andrade M FF, Da Silva J (2016). Protective effects of acerola juice on genotoxicity induced by iron in vivo Molecular genetics. Biology 39(1):122-128.

 

Howerton E, Tarzami T (2017). Tumor Necrosis Factor-Alpha and Inflammation-Mediated Cardiac Injury. Journal of Cell Science and Therapy 8:268.
Crossref

 

Institute of laboratory animals' resources, Commission on life sciences, National research council (1996). Guide for the care and use of laboratory animals. National Academy Press.

 

Jammal M, Da silva A, Filho M, Côbo C, Adad J, Murta C, Nomelini S (2015). Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms. Oncology Letter 9(2):979-983.
Crossref

 

Joslin J (2009): Blood collection: Techniques in exotic small mammals. Journal of Exotic Pet Medicine 18(2):117-139.
Crossref

 

Kehrer P (2000). The Haber–Weiss reaction and mechanisms of toxicity. Toxicological 149:43-50.
Crossref

 

Kell B (2010).Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples," Archives of Toxicology 84(11):825-889.
Crossref

 

Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo L, Theoharides C (2005). Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. British Journal of Pharmacology 145:934-944.
Crossref

 

Khan F, Niaz K, Maqbool F, Hassan H, Abdollahi M, Kalyan C, Venkata N, Nabavi M, Bishayee A (2016). A Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update Nutrients 8(9):529.
Crossref

 

Kleemann R, Verschuren L, Morrison M, Zadelaar S, van EJ, Wielinga, Y, Kooistra T (2011). Anti-inflammatory, anti-proliferative and antiatherosclerotic effects of quercetin in human in vitro and in vivo models. Atherosclerosis 218:44-52.
Crossref

 

Kohgo Y, Ikuta K, Ohtake T, Torimoto Y, Kato J (2008). Body iron metabolism and pathophysiology of iron overload. International Journal of Hematology 88(1):7-15.
Crossref

 

Koracevic D, Koracevic G (2001). Total antioxidant capacity. Journal of Clinical Pathology 54:356-361.
Crossref

 

Kozlowski H, Janicka-Klos A, Brasun J, Gaggelli E (2009). Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation). Coordination Chemistry Reviews 253:2665-2685.
Crossref

 

Kremastinos T, Farmakis D, Aessopos A, Hahalis G, Hamodraka E, Tsiapras D (2010). Betathalassemia cardiomyopathy: history, present considerations, and future perspectives. Circulation Heart Failure 3(3):451-458.
Crossref

 

Kulaksiz H, Fein E, Redecker P, Stremmel W, Adler G, Cetin Y (2008). Pancreatic b-cells express hepcidin, an iron-uptake regulatory peptide. Journal of Endocrinology 197:241-249.
Crossref

 

Lebda M (2014). Acute Iron Overload and Potential Chemotherapeutic Effect of Turmeric in Rats. International Journal of Pure and Applied Bioscience 2(2):86-94.

 

Leopoldini M, Sandro C, Marisosa T (2006). Iron chelation by the powerful antioxidant flavonoid quercetin. Journal of Agricultural and Food Chemistry 54:6343-6351.
Crossref

 

Li Y, Hansen L, Borst B, Spears W, Moeser J (2016a). "Dietary iron deficiency and over supplementation increase intestinal permeability, ion transport, and inflammation in pigs," Journal of Nutrition 146(8):1499-1505.
Crossref

 

Li Y, Yao J, Han Ch, Yang J, Chaudhry T, Wang S, Liu H, Yin Y, (2016b). Quercetin, Inflammation and Immunity. Nutritional 8:167
Crossref

 

Madhusudhan S, Oberoi R (2011). Renal iron deposition in aplastic ane-mia: magnetic resonance imaging appearance. Indian Journal of Nephrology 21:134-135.
Crossref

 

Matos R, Capelozzi L, Gomes F, Mascio D, Medeiros H (2001). Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilo tri acetate. Archives of Biochemistry and Biophysics 396:171-177.
Crossref

 

Nijveldt J, van Nood E, van Hoorn C, Boelens G, van Norren K, van Leeuwen M (2001)."Flavonoids: a review of probable mechanisms of action and potential applications," American Journal of Clinical Nutrition 74(4):418-425.
Crossref

 

Ohkawa H, Ohishi W, Anal K (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95:351-358.
Crossref

 

Nunez T, Urrutia P, Mena N, Aguirre P, Tapia V, Salazar J (2012): "Iron toxicity in neurodegeneration," Biometals 25(4):761-776.
Crossref

 

Pari L, Asaithambi K, Paramasivam K, Ayyasamy R (2015). Protective effects of hesperidin on oxidative stress, dyslipidaemia and histological changes in iron-induced hepatic and renal toxicity in rats. Toxicology Reports 2:46-55.
Crossref

 

Porter B (1997). A risk-benefit assessment of iron-chelation therapy. Drug Safety 17:407-21.
Crossref

 

Qi L, Cao C, Hu L, Chen S, Zhao X, Sun C (2017). Metabonomic analysis of the protective effect of quercetin on the toxicity induced by mixture of organophosphate pesticides in rat urine:Human and Experimental Toxicology 36(5):494-507.
Crossref

 

Raza A, Xu X, Xia L, Xia C, Tang J, Ouyang Z (2016). Quercetin-Iron Complex: Synthesis, Characterization, Antioxidant, DNA Binding, DNA Cleavage, and Antibacterial Activity Studies: Journal of Fluorescence 26:2023-2031.
Crossref

 

Singh P, McCoy T, Tice R, Schneider L (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Experimental Cell Research 175(1):184-191.
Crossref

 

Sinha R, Srivastava S, Joshi A, Joshi J, Govil G (2014). In-vitro anti-proliferative and anti-oxidant activity of galangin, fisetin and quercetin: role of localization and intermolecular interaction in model membrane. European Journal of Medicinal Chemistry 79: 102-109.
Crossref

 

Stookey LL (1970). "Ferrozine-A New Spectrophotometric Reagent for Iron," Analytical Chemistry 42(7):779-781.
Crossref

 

Tice R, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae E, Ryu C, Sasaki F (2000). Single cell gel/ cometassay: guidelines for in vitro and in vivo genetic toxicology testing. Environmental and Molecular Mutagenesis 35:206-221.
Crossref

 

Torreggiani A, Tamba M, Trinchero A, Bonora S (2005). Copper (II)–Quercetin complexes in aqueous solutions: spectroscopic and kinetic properties. Journal of Molecular Structure 744:759-766.
Crossref

 

Torti V, Torti M (2013). Iron and cancer:more ore to be mined. Nature Reviews Cancer 13: 342-355.
Crossref

 

Uranga M, Salvador A (2018). Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology. Oxidative Medicine and Cellular Longevity, Article ID 2850341, 12.
Crossref

 

Urrutia P, Aguirre A, Esparza A, Tapia V (2013). Inflammation alters the expression of DMT1, FPN1 and hepcidin and causes iron accumulation in central nervous system cells. International Society for Neurochemistry. Journal of Neurochemistry 126:541-549.
Crossref

 

Uzun G, Demir F, Kalender S (2010). Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats. Food and Chemical Toxicology 48:1714-1720.
Crossref

 

Uzun G, Kalender Y (2013). Chlorpyrifos induced hepatotoxic and hematologic changes in rats: the role of quercetin and catechin. Food and Chemical Toxicology 55:549-556.
Crossref

 

Valko M, Rhodes J, Moncol J, Izakovic M, Mazur M (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico- Biological Interactions 160:1-40.
Crossref

 

Valko M, Morris H, Cronin T (2005). Metals, toxicity and oxidative stress. Current Medicinal Chemistry 12:1161-1208.
Crossref

 

Von Bernhardi R, Eugenin J (2012). Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms. Antioxidants and Redox Signaling 16:974-1031.
Crossref

 

Yang J, Cao J, Sun X, Feng Z, Hao D, Zhao X, Sun C (2012). Effects of long-term exposure to low levels of organophosphorous pesticides and their mixture on altered antioxidative defense mechanisms and lipid peroxidation in rat liver. Cell Biochemistry and Function 30:122-128.
Crossref

 

Zantopoulos V, Antoniou V, Pet saga V, Zdrags A (1996). "Copper concentration in sheep liver and kidney in Greece," Veterinary and Human Toxicology 38(3):184-185.

 

Zhang Y, Li H, Zhao Y, Gao Z (2006). "Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury," European Journal of Pharmacology 535(30):263-269.
Crossref

 

Zhang Y, Gao Z, Liu J, Xu Z (2011). Protective effects of baicalin and quercetin on an iron-overloaded mouse: comparison of liver, kidney and heart tissues. Natural Product Research 25(12):1150-1160.
Crossref

 

Zivadinov R, Weinstock-Guttman B, Pirko I (2011). Iron deposition and inflammation in multiple sclerosis. Which one comes first? BMC Neuroscience 12:60.
Crossref